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IRCT20191002044951N1 IRCT 2019-11-04 Iran University of Medical Sciences Comparison of the therapeutic effect of corticosteroid injection with hypertonic dextrose in patients with knee osteoarthritis Comparison of therapeutic effect of corticosteroid injection with hypertonic dextrose in patients with knee osteoarthritis 2019-11-05 anticipated 54 Complete https://irct.ir/trial/42684 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization, in which each member of the community has an equal chance of being independent, is chosen. The randomization method will be used with random and binary blocks. Regarding the sample size of 54 people, 13 quadruple blocks and 1 binary block will be generated and numbered using the permutations method. Using the random number table , blocks will be placed together to form a patient allocation sequence to treatment groups. Providers will be unaware of the type of treatment that will be received, as well as the random sequences generated in The length of the study will be unpredictable, Blinding description: Patients and analyzers are unaware of the drugs given to the control and intervention groups. 3 Knee Osteoarthritis. Intervention 1: Intervention group 1 : Under sterile conditions, 5cc dextrose hypertonic 20% is injected into the knee joint through the supra peltar patch.Injection with 25 gage needle is performed . Before injection, pain severity and WOMAC score and clinical evaluation (ROM) were determined in both groups of patients and these criteria were evaluated one week, one month and three months after injection. Intervention 2: Intervention group 2: Under sterile conditions, 40 mg triamcinolone is injected via suprapetellar patch into the knee joint (in one session).Injection with 25 gage needle is performed . Before injection, pain severity and WOMAC score and clinical evaluation (ROM) were determined in both groups of patients and these criteria were evaluated one week, one month and three months after injection. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.
public Forugh Zarnegar
Firoozgar Hospital, Beh afarin Ave, Valiasr Square, Tehran, Iran
Tehran Iran (Islamic Republic of) 1593747811 +98 21 4128 9221 Forugh.zarnegar@gmail.com Iran University of Medical Sciences scientific Koorosh Mansoori
Firoozgar Hospital, Behafarin Ave, Valiasr Square, Tehran, Iran
Tehran Iran (Islamic Republic of) 1593747811 +98 21 4128 9221 Kmansoorimd@yahoo.com Iran University of Medical Sciences Iran (Islamic Republic of) All knee osteoarthritis patients with Grade 1 and 2 All knee osteoarthritis patients between the ages of 1 and 2 years 40 years 75 years Both Age less than 2 years and more than 5 years Osteoarthritis with Grade 1 and 2 Pregnancy Severe underlying disease M17.0 Bilateral primary osteoarthritis of knee Treatment - Drugs Treatment - Drugs Intervention group 1 : Under sterile conditions, 5cc dextrose hypertonic 20% is injected into the knee joint through the supra peltar patch.Injection with 25 gage needle is performed . Before injection, pain severity and WOMAC score and clinical evaluation (ROM) were determined in both groups of patients and these criteria were evaluated one week, one month and three months after injection. Intervention group 2: Under sterile conditions, 40 mg triamcinolone is injected via suprapetellar patch into the knee joint (in one session).Injection with 25 gage needle is performed . Before injection, pain severity and WOMAC score and clinical evaluation (ROM) were determined in both groups of patients and these criteria were evaluated one week, one month and three months after injection. The severity of pain. Timepoint: Zero,one week,one month and three month after. Method of measurement: Visual Analog Scale(VAS). The severity of symptoms and functional limitations. Timepoint: Zero,one week,one month and three month after. Method of measurement: WOMAK questionnaire. Range of motion. Timepoint: Zero,one week,one month and three month after. Method of measurement: Goniometer. Iran University of Medical Sciences Approved 2019-01-15 Ethics committee of Iran University of Medical Sciences Valiasr Square, Behafarin Street, Firoozgar Hospital Tehran Tehran Iran (Islamic Republic of)