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IRCT20191006045004N1 IRCT 2019-11-15 Shahrekord University Effect of exercise on immune and inflammatory factors in MS patients The effect of eight weeks of combined training on the expression of some anti-antimicrobial and micro-RNAS related to immune, TLR-4 and TLR-2 in patients with multiple sclerosis 2019-06-21 anticipated 24 Complete https://irct.ir/trial/42785 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Basic scienece, Randomization description: Subjects will be selected based on the criteria for entering the study as well as other necessary examinations. Than, the subjects will be randomly assigned (simple lottery) to the experimental and control groups. The simple lottery method in this study is done first; the names of all the people in accordance with the inclusion criteria; without observing the specific order on the paper pieces and placed inside the box (A total; 24 of them will select).Then mix the paper and the first 12 numbers whose names came out of the box in the experimental group and the next 12 people will be placed in the control group. N/A Multiple sclerosis. Intervention 1: Intervention group: Exercise training Protocol In this study, 32 training sessions, which included a total of 8 weeks of training and 4 sessions of training each week. 3 sessions will be aerobic training (bicycle and treadmill) and one session of resistance training. Cardio workouts are performed on Saturday, Sunday and Monday, and the Resistance training program is performed on Wednesday every week. Intervention 2: Control group: The group will not receive any exercise activity. Yes - There is a plan to make this available What will be shared: In this section, part of anthropometric information (height, weight and BMI), and information about the main outcomes of the study are shared after non-identifying people to print to a reputable magazine. When: Start the access period 3 months after printing results To whom: Only for researchers working in academic and academic institutions. Conditions: 1-If needed, and as a non-personally identifiable data, only the journals that the article will be sent to the printing. 2. Physicians in this study Where to obtain: Saman Yousefi Saqqezi Email: samanyousefi25@yahoo.com How to obtain: Confirmation of the relevant advisor and finally approved from vice chancellor for research and technology, University of Shahrekord Comments:
public Saman Yousefi Saqqezi
No. 1, Ansar Street, Farhang Blvd.
Shahrekord Iran (Islamic Republic of) 8817976389 +98 38 3225 4315 samanyousefi25@yahoo.com Shahrekord University scientific Saman Yousefi Saqqezi
No. 1, Ansar Street, Farhang Blvd.
Shahrekord Iran (Islamic Republic of) 8817976389 +98 38 3225 4315 samanyousefi25@yahoo.com Shahrekord University Iran (Islamic Republic of) Confirmed diagnosis of definite relapsing and remitting MS (RRMS) An Expanded Disability Status Scale (EDSS) Score of 1 to 4 No history of any medical condition, that would preclude participation in the exercise program Ability to participate in exercise No Participants in regular exercise in the last 6 months The age range of 20 - 40 years 20 years 40 years Female Comorbidities that prevent participation (cardiovascular disease: metabolic disease: etc.) Corticosteroid treatment Body injury that they effectively cannot participate in the exercise program Pregnancy G35 Multiple sclerosis Lifestyle Lifestyle Intervention group: Exercise training Protocol In this study, 32 training sessions, which included a total of 8 weeks of training and 4 sessions of training each week. 3 sessions will be aerobic training (bicycle and treadmill) and one session of resistance training. Cardio workouts are performed on Saturday, Sunday and Monday, and the Resistance training program is performed on Wednesday every week. Control group: The group will not receive any exercise activity The expression rate of anti-antimicrobial peptides hBD-2 and LL-37. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: Measurement kits for measuring the hBD-2 and LL-37 variables with methods Real Time-PCR. Expression rate of micro-RNAS 155; 326; 23b; 146a; 21. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: Measuring kits for measuring the expression of micro-RNAS 155; 326; 23b; 146a; 21 by method Real Time -PCR. Expression rate of TLR-4; TLR-2. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: Measurement kits for measuring the expression of TLR-4 and TLR-2 with Real Time-PCR method. Expanded Disability Status Scale. Timepoint: Before and after 8 weeks of combined training (aerobic + resistance). Method of measurement: EDSS Test. Shahrekord University Approved 2019-06-30 Ethics Committee in Research Sport Sciences Research Institute No,3, 5th St., Mir Emad St., Motahari Ave., Tehran, Iran. Tehran Tehran Iran (Islamic Republic of)