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IRCT20151123025202N3 IRCT 2019-11-23 Hamedan University of Medical Sciences Effectivness of Topical Furesemaide chronic on rhinosinusitis surgery Study on Effectivness of Topical Furesemaide administration on intraoperative blood loss and quality of the surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis 2019-11-22 anticipated 72 Complete https://irct.ir/trial/42823 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: For this purpose, hexagonal block randomization is used. Hence, six sheets of paper were prepared and written on the three letters A ( Intervention group) and on the other three letters B ( control group). Each patient was randomly assigned to one of the two intervention or the control . Recipients of nasal spray will be assigned. It should be noted that the sheets were drawn until all six sheets were removed to the drawer. After randomly pulling out all six sheets, all sheets will be returned to the drawer again and the operation will be continued for the next six patients until the desired sample size is reached, Blinding description: Drug and placebo containers will be designed and coded in the same fashion by the pharmacist. The patient will not be aware of the spray content used. Also, the surgeon who will measure and record the outcome of the study will not be aware of the spray content used. 1-2 chronic rhino sinusitis. Intervention 1: Intervention group: receive one Puff of Furzemide spray (20 micrograms per puff equivalent to 40 micrograms) in each nasal side daily from one week before surgery. Intervention 2: Control group: receive one Puff of normal saline in each nasal side daily from one week before surgery. Yes - There is a plan to make this available What will be shared: The data on the method of work and the outcome of the intervention can be shared When: After the end of the study and for an unlimited period To whom: Medical students and graduates Conditions: For study and publication with citation and meta-analysis studies Where to obtain: refer to Scientific responsible How to obtain: Submit request by email address listed Comments:
public Abbass Moradi
No 5 Fath, Pirouzi, Ammar
Hamedan Iran (Islamic Republic of) 6515974544 +98 81 3823 5480 a.moradi@umsha.ac.ir Hamedan University of Medical Sciences scientific Javane Jahanshahi
Shahid Fahmideh Ave
Hamedan Iran (Islamic Republic of) 6517838677 +98 81 3838 0097 jahanshahi287@gmail.com Hamedan University of Medical Sciences Iran (Islamic Republic of) Patients with chronic rhinosinusitis with or without polyposis (primary or recurrent) Ages between 18 and 60 years Normalization of PT, PTT, INR, BT, CT and platelet count 18 years 60 years Both have Bleeding disorders such as uncontrolled hemophilia Uncontrolled history of thromboembolic events Uncontrolled Receive heparin at 48 hours before surgery ake aspirin within 3 days before surgery Allergies to Furesemaide Liver Cirrhosis Systemic diseases such as hypertension, diabetes, heart failure Patients with sinonasal tumor side effects of Furesemaide acute or chronic renal failure Cardiac stent Js32.9 js32.9 Treatment - Drugs Placebo Intervention group: receive one Puff of Furzemide spray (20 micrograms per puff equivalent to 40 micrograms) in each nasal side daily from one week before surgery. Control group: receive one Puff of normal saline in each nasal side daily from one week before surgery. Reduce bleeding in surgery site. Timepoint: end of surgery time. Method of measurement: The amount of blood collected in the suction bottle (after deduction of normal saline volume) and the weight of blood-stained packs. Quality of vision of the surgical field. Timepoint: during the surgery. Method of measurement: with Boezaart Grading questionair. Hamedan University of Medical Sciences Approved 2019-09-28 ethics committee of Hamedan University of medical science shahid fahmide Ave Hamedan Hamadan Iran (Islamic Republic of)