IRCT20191006045001N1 IRCT 2020-01-26 Kashan University of Medical Sciences The effect of probiotics in treatment of patients undergoing breast cancer chemotherapy The effect of probiotics on quality of life and inflammatory and oxidative stress biomarkers in patients undergoing breast cancer chemotherapy 2019-10-30 anticipated 60 Complete https://irct.ir/trial/42908 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Participants were randomly assigned to receive either probiotic (n = 30) or placebo (n = 30) based on randomized block randomization. Blocks of size 2, 4 and 6 are used. Rand software was used for randomization. Closed envelopes were used to hide the randomization process, which were opened at the time of patient's visit to minimize the gap between randomization and drug or placebo, Blinding description: Randomization and allocation will be concealed from the researchers and participants until the final analyses will be completed. Another person who is not involved in the trial and not aware of random sequences, will be assigned the participants to the numbered bottles of capsules. 3 breast cancer. Intervention 1: Intervention group: Probiotic capsule containing 4 strains of Bifidobacterium lactis (1/8×109 units per gram), Lactobacillus acidophilus (1/8×109 units per gram), Bifidobacterium bifidum (1/8×109 units per gram) G), Bifidobacterium langum (1/8×109 units / g) daily, orally for 12 weeks. Intervention 2: Control group: placebo capsules, daily, orally for 12 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this available