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IRCT201008184105N3 IRCT 2010-09-16 Deputy of Tabriz University of Medical Sciences Effect of vitamin A supplementation on immune system indices in patients with ulcerative colitis Effect of vitamin A supplementation on immune system indices in patients with ulcerative colitis 2010-04-22 anticipated 43 Complete https://irct.ir/trial/4302 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 2 Condition 1: Ulcerative colitis. Condition 2: Ulcerative colitis. Condition 3: Ulcerative colitis. Condition 4: Ulcerative colitis. Vitamin A supplement, as injections, twice (14 days interval), 50000 IU per injection.
public
scientific Dr Ostadrahimi
Health & Nutrition Faculty of Tabriz Medical Science University
Tabriz Iran (Islamic Republic of) +98 41 1335 7581 ostadrahimi@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: presence of ulcerative colitis, age range 20 to 45 years, signing consent, receiving similar medications during 6 months prior to the intervention, (a Salazyny drugs: Azathioprine, sulfasalazine) Exclusion criteria: Presence of any autoimmune disease (disease, MS, lupus erythematosus), chronic exposure to any infectious disease, inflammation, diabetes or cancer, consumption of any food supplement such as multivitamin- mineral, vitamin A, zinc and vitamin D and omega-3), use any type of anti-inflammatory drugs such as NSAIDS and immunosuppressives (cyclosporine and ...), pregnancy or intention to become pregnant, any surgery during six months prior to the study, BMI more than 30 20 years 50 years Both K51.1 K51.0 K51.2 K51.3 Ulcerative (chronic) ileocolitis Ulcerative (chronic) enterocolitis Ulcerative (chronic) proctitis Ulcerative (chronic) rectosigmoiditis Treatment - Other Vitamin A supplement, as injections, twice (14 days interval), 50000 IU per injection CD4 lymphocyte count. Timepoint: before & after (day 0 & 45). Method of measurement: flowcytometery. Proinflammatory cytokine (IL12). Timepoint: before & after (day 0 & 45). Method of measurement: ELISA. Acute phase protein(hs-CRP). Timepoint: before & after (day 0 & 45). Method of measurement: turbidometeric. Anti inflammatory cytokine(IL10 & IL4). Timepoint: before & after (day 0 & 45). Method of measurement: ELISA. Serum retinol. Timepoint: before & after (day 0 & 45). Method of measurement: HPLC. Clinical symotoms. Timepoint: before & after (day 0 & 45). Method of measurement: trouvel witt index. Food intake habits & dietary intake. Timepoint: before & after (day 0 & 45). Method of measurement: FFQ & dietary record (3 days). Nutrition research center Gastroentrology & Liver Research Center Deputy of Tabriz University of Medical Sciences Nutrition research center Gastroentrology & Liver Research Center Approved Vice chancellor for research of Tabriz University of Medical Sciences Tabriz University of Medical Sciences Tabriz Iran (Islamic Republic of)