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IRCT20191014045106N1 IRCT 2020-02-19 Shahid Beheshti University of Medical Sciences Comparison of Oral Misoprostol Tablets and Oxytocin for the Induction of Labor inPremature Rupture of Membranes مقایسه اثر میزوپرستول خوراکی و اکسی توسین وریدی در القا زایمان Comparison of Oral Misoprostol Tablets and Oxytocin for the Induction of Labor inPremature Rupture of Membranes 2019-11-22 anticipated 160 Complete https://irct.ir/trial/43101 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: This study was a clinical trial involving 160 pregnant mothers, ranging from 34 to 42 week Pregnancy is referred to premature rupture of the embryo and go to Mahdieh Hospital Will do, it will be done. cervical examination and Bishop score and description It will be done. After definitive diagnosis of splenic rupture in speculum or positive fren test, patients are randomly divided into two groups for induction of labor. 3 Labor in premature rupture of fetal protective membranes. Intervention 1: Intervention group:The case group will be given 50 micrograms of misoprostol orally every 4 hours up to a maximum of 5 doses. Intervention 2: Control group:In the control group, oral placebo and intravenous oxytocin in ringer serum will be started at a dose of 2mlu / min and will be performed every 2 minutes up to 40mlu / min. Yes - There is a plan to make this available What will be shared: Comparison of Oral Misoprostol Tablets and Oxytocin for the Induction of Labor in Premature Rupture of Membranes, All of its results can be used to manage diseases. When: Access 5 months after the results are published To whom: Academic and scientific researchers Conditions: Management and Medical Care Where to obtain: Mahdieh Hospital or Shahid Beheshti University of Medical Sciences How to obtain: In a Written Letter to the Documentation Authorities of Mahdie Hospital of Shahid Beheshti Medical University Comments:
public Maryam Mohammadi
Mahdieh Hospital, Boroujerdi Street
Tehran Iran (Islamic Republic of) 1234567890 +98 21 5506 2644 dr.maryam671@gmail.com Shahid Beheshti University of Medical Sciences scientific Maryam Mohammadi
Mahdieh Hospital, Boroujerdi Street
Tehran Iran (Islamic Republic of) 1234567890 +98 21 5506 2644 dr.maryam671@gmail.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Definitive diagnosis of rupture of the sachet on examination with speculum or positive frenne test Gestational age between 34 and 42 weeks Cephalic presentation Bishop score ≤5 Indication of vaginal termination of pregnancy Parity less than five Absence of active labor Absence of active labor no limit no limit Female The presence of any fetal heart rate abnormalities A history of cesarean section or uterine scarring Contraindications for vaginal delivery such as placenta peria Known allergy to prostaglandin (skin manifestations, hives, rash, shortness of breath, cough, chest pain and blurred vision after previous prostaglandin use) Estimated baby weight over 4 kg Active labor means at least 3 contractions with sufficient force and duration of at least 40 seconds within 10 minutes. Active cardiovascular disease, asthma, glaucoma Vaginal bleeding Z00.12 Encounter for routine child health examination Treatment - Drugs Placebo Intervention group:The case group will be given 50 micrograms of misoprostol orally every 4 hours up to a maximum of 5 doses. Control group:In the control group, oral placebo and intravenous oxytocin in ringer serum will be started at a dose of 2mlu / min and will be performed every 2 minutes up to 40mlu / min. Age. Timepoint: Baseline. Method of measurement: questionnaire. Pregnancy age. Timepoint: Baseline. Method of measurement: questionnaire. Delivery time. Timepoint: During delivery. Method of measurement: questionnaire. First and fifth minute apgar. Timepoint: First and fifth minute. Method of measurement: Based on Apgar score determination by examiner. Postpartum hemorrhage. Timepoint: Immediately after delivery. Method of measurement: View by examiner / Yes, No. Excretion of neonatal meconium. Timepoint: After birth. Method of measurement: View by examiner / Yes, No. Side Effects Of Misoprostol. Timepoint: Postpartum. Method of measurement: Question about person / fever, nausea, Vomiting, diarrhea. Shahid Beheshti University of Medical Sciences Approved 2019-09-04 Ethics committee of Shahid Beheshti University of Medical Sciences Shahid Beheshti University of Medical Sciences, Arabi Ave, Daneshjoo Blvd, Velenjak, chamran highway,Tehran, Iran.7th Floor, Bldg No.2 . Tehran Tehran Iran (Islamic Republic of)