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IRCT20141209020258N125 IRCT 2019-12-13 Arak University of Medical Sciences Comparison characteristics of Supraclavicular block with bupivacaine 0.5% plus dexmedetomidine and granisetron and Magnesium sulphate in upper extremity orthopedic surgeries Comparison characteristics of Supraclavicular block with bupivacaine 0.5% plus dexmedetomidine and granisetron and Magnesium sulphate in upper extremity orthopedic surgeries 2019-09-23 anticipated 105 Complete https://irct.ir/trial/43223 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple individual randomization with randomization with envelopes in three groups A and B and C.‏ In this method, we selected a number of cards or letters as an intervention group and the same ‎number of cards for the control group, then the cards were merged. One card was taken out and its ‎allocation was registered and the card was returned to the other cards after leaving. Then the cards ‎are merged again and we remove another card. This process continues to reach a random sequence ‎according to sample size.‏, Blinding description: This study is double blind. Researcher who complete questionnaire and analyzer and participant are blind (double blind). Outcome assessor and analyzer don't aware from grouping.The person evaluating the outcome is unaware of the grouping. Groups A and B and C are available to analyzer and outcome assessor.The drugs in each group are prepared by the anesthesiologist. They are covered with letters A, B and C. Block is performed by a specialist assistant who is unaware of the medication and interns complete the questionnaires.Internet are also unaware of grouping. 3 Upper extremity fractures. Intervention 1: Intervention group 1: We will inject 25 milliliter Bupivacaine 0.5% plus 1 micro gram in kilogram Dexmedetomidine. Intervention 2: Intervention group 2: We will inject 25 milliliter Bupivacaine 0.5% plus 100 milligram of diluted magnesium sulfate with 2 milliliter of normal saline. Intervention 3: Intervention group 3: We will inject 25 milliliter Bupivacaine 0.5% plus 3 milligram(3 milliliter)Granisetron. Yes - There is a plan to make this available What will be shared: When we publish article in journal Data in SPSS file When: After the article is published To whom: researcher in university Conditions: If there are additional questions Where to obtain: Dr Modir How to obtain: They have to write letters to the professors and the university Comments:
public Dr Behnam Mahmodie
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 mahmodie@arakmu.ac.ir Arak University of Medical Sciences scientific Dr Hesamedin Modir
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 modir.he@gmail.com Arak University of Medical Sciences Iran (Islamic Republic of) Both of gender 20 to 70 years ASA class I and II Candidate for orthopedic surgery of upper limb Body mass index lower than 35 20 years 70 years Both There is more than one body fracture or surgery Coagulation diseases and disorders in PT,PTT, INR Psychological problems Pregnancy Neurological disorders in the hand S52.9 Unspecified fracture of forearm Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 1: We will inject 25 milliliter Bupivacaine 0.5% plus 1 micro gram in kilogram Dexmedetomidine. Intervention group 2: We will inject 25 milliliter Bupivacaine 0.5% plus 100 milligram of diluted magnesium sulfate with 2 milliliter of normal saline. Intervention group 3: We will inject 25 milliliter Bupivacaine 0.5% plus 3 milligram(3 milliliter)Granisetron. Duration of motor block. Timepoint: Every 5 minute. Method of measurement: Physical examination. Duration of Sensory block. Timepoint: Every 1 minute. Method of measurement: Physical examination. Pain. Timepoint: Recovery and 2 and 4 and 8 and 12 and 24 hours after surgery. Method of measurement: Visual Analogue Scale Questionnaire. Arak University of Medical Sciences Approved 2019-09-22 Ethics Committee Of Arak University Of Medical Sciences Research Center, Payambar Azam Complex, Basij square, Sardasht, Arak Arak Markazi Iran (Islamic Republic of)