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IRCT138903164106N1 IRCT 2010-10-26 Vice chancellor for research, Babol University of Medical Sciences Histologic and Histomorphometric Evaluation of Natix Synthetic Biomaterial in Horizontal Alveolar Ridge Augmentation Histologic and Histomorphometric Evaluation of Natix Synthetic Biomaterial in Horizontal Alveolar Ridge Augmentation 2010-03-06 anticipated 10 Complete https://irct.ir/trial/4326 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Other. N/A Histologic and histomorphometric analysis of horizontal alveolar ridge augmentation. After reflection of a full-thickness flap for gaining access to the buccal bone of edentulous ridge, Natix biomaterial is mixed with blood and saline and then placed on the area of bone defect. Then the augmneted area will be covered by Cytoplast resorbable membrane. Without any tension the flaps are tied together. 8 month after surgery, full thickness flaps are reflected for the purpose of implant surgery. Biopsy specimens in shape of a bone core are harvested from the area of implant insertion. Specimens are sended to laboratory for histologic and histomorphometric study..

public Dr Javad Mehrani Sabet

Depatment of Periodontics, Faculty of dentistry, Medical Uneversity, Ganjafrooz avenue

Babol Iran (Islamic Republic of) +98 11 1222 4032 j.mehrani@mubabol.ac.ir Babol University of Medical Sciences, Faculty of Dentistry scientific Dr Javad Mehrani Sabet

Depatment of Periodontics, Faculty of dentistry, Medical Uneversity, Ganjafrooz avenue

Babol Iran (Islamic Republic of) +98 11 1222 4032 j.mehrani@mubabol.ac.ir Babol University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: 1- Patients ranging from 30 to 50 years old 2- Patients demanding implant treatment in posterior regions of mandibular alveolar ridge 3- Sufficient vertical height of bone in posterior mandibular region with inadequate buccolingual width (width of less than 5 mm and minimum width of 2 mm) 4- Healthy patients 5- Minimum of one augmentation site for each patient requiring implant treatment. Exclusion criteria: 1- Patients having systemic conditions affecting healing such as: Uncontrolled Diabetes, Immune diseases, Systemic or local diseases of bone, history of Alcoholism, Patients taking Immunosuppressive or Anticoagulant medications 2- poor compliance 3- Patients having untreated active periodontal disease 4- Patients unable to maintain oral health status or not interested in maintaining oral health status. 30 years 50 years Both K08 Other disorders of teeth and supporting structures Treatment - Other After reflection of a full-thickness flap for gaining access to the buccal bone of edentulous ridge, Natix biomaterial is mixed with blood and saline and then placed on the area of bone defect. Then the augmneted area will be covered by Cytoplast resorbable membrane. Without any tension the flaps are tied together. 8 month after surgery, full thickness flaps are reflected for the purpose of implant surgery. Biopsy specimens in shape of a bone core are harvested from the area of implant insertion. Specimens are sended to laboratory for histologic and histomorphometric study. Histologic and Histomorphometric Evaluation of effect of Natix Synthetic Biomaterial in Horizontal Alveolar Ridge Augmentation. Timepoint: 8 months after intervention. Method of measurement: Biopsy specimens are taken from the augmented site by Natix, and are stained with Hematoxilin & Eosin and parameters such as: 1-amount of inflammation 2-existence or inexistence of foreign body reaction (giant cells and granulomatous reactions) 3-Bone vitality (Existence or inexistence of osteocytes in lacunaes) 4-Thickness of bone trabecules 5-Way of contact between bone-biomaterial (existence or inexistence of connective tissue between bone fragments) are analysed. Vice chancellor for research, Babol University of Medical Sciences Approved Babol University of Medical Sciences Periodontic Department, Faculty of Dentistry, Medical University, Ganjafrooz Avenue Babol Iran (Islamic Republic of)