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IRCT20141209020258N123 IRCT 2019-11-02 Arak University of Medical Sciences Comparison of the effect of adding Dexmedetomidine, Granisetron and Nitroglycerin to Rupivacaine in Reducing Pain and Hemodynamic Changes in intravenous regional anesthesia of forearm surgery Comparison of the effect of adding Dexmedetomidine, Granisetron and Nitroglycerin to Rupivacaine in Reducing Pain and Hemodynamic Changes in intravenous regional anesthesia of forearm surgery 2019-07-23 anticipated 128 Complete https://irct.ir/trial/43294 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple individual randomization with randomization with envelopes in two groups A and B and C.‏ In this method, we selected a number of cards or letters as an intervention group and the same ‎number of cards for the control group, then the cards were merged. One card was taken out and its ‎allocation was registered and the card was returned to the other cards after leaving. Then the cards ‎are merged again and we remove another card. This process continues to reach a random sequence ‎according to sample size.‏, Blinding description: This study is double blind. Researcher who complete questionnaire and analyzer and participant are blind (double blind). Outcome assessor and analyzer don't aware from grouping.The person evaluating the outcome is unaware of the grouping. Groups A and B and C are available to analyzer and outcome assessor. 3 forearm surgery. Intervention 1: Intervention group: We will inject 0/5 micro gram in kilogram co.Dexmedetomidine (Exir Co.Iran) plus 35 milliliter Rupivacaine 0/2%(Molteni Co.Italia). Intervention 2: Intervention group: we will inject 2 milligram Granisetron(Caspian Co.Iran) plus 35 milliliter Rupivacaine 0/2%(Molteni Co.Italia). Intervention 3: Intervention group: We will inject 200 micro gram Nitroglycerin (Caspian Co.Iran) plus 35 milliliter Rupivacaine 0/2%(Molteni Co.Italia). Intervention 4: Control group: we will inject 5 milliliter normal saline plus 35 milliliter Rupivacaine 0/2%(Molteni Co.Italia). Yes - There is a plan to make this available What will be shared: When we publish article in journal When: After the article is published To whom: researcher in university Conditions: If there are additional questions Where to obtain: Dr Moshiri How to obtain: They have to write letters to the professors and the university Comments:
public Dr Hesamedin Modir
Valiasr Hospital, Valiasr squre, Shahid Shirodi street
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 modir.he@gmail.com Arak University of Medical Sciences scientific Dr Esmaeel Moshiri
Shahid Shirodi street, Valiasr square, Valiasr hospital
Arak Iran (Islamic Republic of) 3814957558 +98 86 3222 2003 moshiri@gmail.com Arak University of Medical Sciences Iran (Islamic Republic of) Both of gender 20 to 65 years Candidate forearm surgery ASA class I and II 20 years 65 years Both Rinod's disease Sickle cell anemia History of allergy to the drugs used in the study Affected limb cyanosis Drugs and psychotropic use There is more than one body fracture or surgery Pregnancy Chronic pain syndrome Neurological disorders in the hand Hypertension-related disease and heart erythema and heart failure S52.9 Unspecified fracture of forearm Treatment - Drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: We will inject 0/5 micro gram in kilogram co.Dexmedetomidine (Exir Co.Iran) plus 35 milliliter Rupivacaine 0/2%(Molteni Co.Italia). Intervention group: we will inject 2 milligram Granisetron(Caspian Co.Iran) plus 35 milliliter Rupivacaine 0/2%(Molteni Co.Italia). Intervention group: We will inject 200 micro gram Nitroglycerin (Caspian Co.Iran) plus 35 milliliter Rupivacaine 0/2%(Molteni Co.Italia) Control group: we will inject 5 milliliter normal saline plus 35 milliliter Rupivacaine 0/2%(Molteni Co.Italia) Duration of motor block. Timepoint: Every 5 minute. Method of measurement: Minute. Duration of Sensory block. Timepoint: Every 1 minute. Method of measurement: Minute. Pain. Timepoint: After filling the tourniquet, at the time of 15, 30 and 45 and every 15 minutes until the end of surgery. Method of measurement: Visual Analogue Scale Questionnaire. Mean use of narcotic. Timepoint: 24 hour after surgery. Method of measurement: Milligram. Arak University of Medical Sciences Approved 2019-07-21 Ethics comittee of Arak University of Medical Sciences Ethics comittee, Research center, Payambar Azam complex, Basij squre ,Sardasht,Arak Arak Markazi Iran (Islamic Republic of)