IRCT20120215009014N314 IRCT 2019-10-29 Hamedan University of Medical Sciences Effect of melatonin versus placebo on the sleep improvement and quality of life in patients with bipolar disorder in the manic phase Effect of melatonin versus placebo on the sleep improvement and quality of life in patients with bipolar disorder in the manic phase: a double-blind randomized clinical trial 2019-11-12 anticipated 60 Complete https://irct.ir/trial/43298 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random assignment of the patients to the intervention and control groups through the drawing of lots. To do this, we prepare two sheets and write "intervention" on one sheet and "control" on another. Then, by referring each patient, one of the sheets will be randomly taken and the patient will be assigned to the intervention or control group, Blinding description: The shape of the medications and placebos will be perfectly the same. Therefore, patients will be unaware of the type of intervention. The physician who will examine the patients will not be aware of the intervention. Thus, the trial will be run as triple-blind. 2 Bipolar disorder. Intervention 1: Intervention group: Routine treatment plus melatonin tablets manufactured by Jairus Company 30 mg every night for one week and then 60 mg every night for three weeks. Intervention 2: Control group: Routine treatment plus placebo tablets manufactured by the School of Pharmacy, Hamadan University of Medical Sciences, one tablet every night for one week and then two tablets every night for three weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is It depends on the situations and the results of the study as well as the approval of the financial supporting organization.