IRCT20160430027677N17 IRCT 2019-12-14 Oroumia University of Medical Sciences Effect of preoperative oral clonidine on shoulder pain in laparoscopic cholecystectomy with general anesthesia Comparison the effect of preoperative oral clonidine and placebo on shoulder pain in laparoscopic cholecystectomy with general anesthesia 2017-04-20 anticipated 64 Complete https://irct.ir/trial/43559 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients will be randomly assigned into two groups of clonidine 150 Micrograms (group C) and placebo (group P) using Random Allocation Software 2.0, and the target codes will be written on a piece of paper and placed in sealed envelopes with sequential allocation, Blinding description: The drug will be administered by the nurse in the ward and at the time of admission, the anesthesiologist will be unaware which patient will be assigned to which group. Drug containers will be identical and only the nurse will know about the contents of each of them, and finally, after collecting information by the resident in training in anesthesiology, the anesthesiology specialist will be informed of the group each patient is assigned to. 2-3 pain. Intervention 1: Intervention group: patients will receive clonidine 150 Microgram oral tablet, 90 minutes before surgery. Intervention 2: Control group: will be received oral placebo 90 minutes before surgery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information