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IRCT20191015045113N1 IRCT 2019-12-08 Shiraz University of Medical Sciences The effect of zinc supplementation on fatty liver Effect of zinc supplementation on serum zinc status, lipid profile, liver enzymes (ALT, AST), insulin resistance, inflammatory markers and oxidative stress in non-alcoholic fatty liver patients 2018-09-23 anticipated 50 Complete https://irct.ir/trial/43583 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Samples were included in this study by simple randomization. In this way, patients were randomly assigned to one of the intervention and placebo groups after having met the inclusion criteria and obtaining written consent.That way the first patient in The intervention group and the next group are included in the control group.This is done until the end of the sample, Blinding description: The patient-level study and the outcome evaluator will be blinded. Medication and placebo capsules are divided into two equal groups before filling on the basis of random number table by block method. Only a researcher based on the initial stored form of randomized results can decode the contents of each capsule. The person responsible for delivering the medication, the patient, the physician, and the outcome assessor will not be aware of the coding. The results of the intervention and control groups will be delivered to the statistical analyst under the titles of groups A and B. 3 Non Alcoholic Fatty Liver Disease. Intervention 1: Intervention group: Twenty - five patients with ultrasound - confirmed non - alcoholic fatty liver disease received a coated capsule containing 30 mg of Nature Made made at the Faculty of Pharmacy of Shiraz University of Medical Sciences for 8 weeks. Intervention 2: Control group: Twenty-five patients with ultrasound-approved non-alcoholic fatty liver were included for 8 weeks with a starch-coated capsule made at Shiraz University of Medical Sciences School of Pharmacy in terms of appearance, size, and color. ... with the complement of zinc they receive. Yes - There is a plan to make this available What will be shared: All data is shared after unidentifiable people When: Start of access period 6 months after printing results To whom: For people working in science institutes Conditions: For meta-analysis studies Where to obtain: seyed mohammad amin rezaei 09177422832 How to obtain: -The applicant can receive the file after up to one month after the call or email. Comments:
public Seyed Mohammad Amin Rezaei
Karkonan Doulat
Gachsaran Iran (Islamic Republic of) 7581359560 +98 74 3232 2519 seyedamin.rezaei69@gmail.com Shiraz University of Medical Sciences scientific Seyed Mohammad Amin Rezaei
Karkonan Doulat
Gachsaran Iran (Islamic Republic of) 7581359560 +98 74 3232 2519 seyedamin.rezaei69@gmail.com Shiraz University of Medical Sciences Iran (Islamic Republic of) -Attention to fatty liver confirmed by ultrasound - Ages between 18 and 70 years -Not consuming alcoholic beverages - Lack of other liver diseases such as viral hepatitis, liver cirrhosis, Wilson's disease ... - Lack of parenteral nutrition -No diseases that affect the bile and bile ducts - No severe weight loss 6 months ago -Not taking medications that cause fatty liver (methotrexate, tamoxifen, valproate, etc.) -No pregnancy and breastfeeding - Lack of serum ALT levels more than 10 times the limit - No chemotherapy during the past year -Not taking any supplements containing zinc 18 years 70 years Both People who have done chemotherapy over the past year People with any biliary disease People taking any supplements and drugs containing zinc People who have had severe weight loss in the past 6 month People taking any form of fatty liver medication K76.0 Fatty (change of) liver, not elsewhere classified Treatment - Drugs Placebo Intervention group: Twenty - five patients with ultrasound - confirmed non - alcoholic fatty liver disease received a coated capsule containing 30 mg of Nature Made made at the Faculty of Pharmacy of Shiraz University of Medical Sciences for 8 weeks. Control group: Twenty-five patients with ultrasound-approved non-alcoholic fatty liver were included for 8 weeks with a starch-coated capsule made at Shiraz University of Medical Sciences School of Pharmacy in terms of appearance, size, and color. ... with the complement of zinc they receive. Serum zinc. Timepoint: 8 weeks. Method of measurement: Blood sampling. Insulin resistance. Timepoint: 8 weeks. Method of measurement: Blood sampling. ALT. Timepoint: 8 Week. Method of measurement: blood sample. Fasting blood sugar. Timepoint: 8 week. Method of measurement: blood sample. Serum total cholesterol. Timepoint: 8 week. Method of measurement: blood sample. Serum triglyceride. Timepoint: 8 Week. Method of measurement: blood sample. MDA. Timepoint: 8 week. Method of measurement: blood sample. Total Antioxidant Capacity (TAC). Timepoint: 8 week. Method of measurement: blood sample. Hs-CRP. Timepoint: 8 week. Method of measurement: blood sample. Vice chancellor for research, Shiraz University of Medical Sciences Shiraz University of Medical Sciences Vice chancellor for research, Shiraz University of Medical Sciences Approved 2019-01-22 Ethics committee of Shiraz University of Medical Sciences Bahman Beigi Boulevard, Bibi Hakime Hospital shiraz Fars Iran (Islamic Republic of)