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IRCT20191112045415N1 IRCT 2019-12-08 Tehran University of Medical Sciences Effect of verb treatment on sentence production in aggrammatism The comparison of effectiveness of regular and irregular past tense treatment on sentence production and neural function in patients with agrammatic aphasia 2020-01-21 anticipated 6 Complete https://irct.ir/trial/43603 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. N/A aphasia. Intervention group: ACTION treatment will be performed on patients with agrammatic aphasia with a focus on verb learning and its tense inflection in sentence structure. The treatment steps are as follows: Stage 1 Syntactic Level: Recovery of nonverbal verbs in sentence context. a picture is shown with a sentence under it, in which the verb, in infinitival form, is left out.The participant reads the sentence (if necessary with the help of the therapist) and has to fill in the missing verb orally. Step 2: Syntactic-syntactic step: Retrieves the verb in the context of the sentence. As in step 1, but here the verb tense has to be inflected correctly . a picture is shown with a sentence under it, in which the verb, in infinitival form, is left out.The participant reads the sentence (if necessary with the help of the therapist) and has to fill in the missing verb orally. Step 3. Sentence construction: An image is shown to the participant and he or she must make a grammatical sentence.. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information
public Vahid Valinejad
Enghelab square, kargar shomali Blvd, Borhany Alley, Enghelab 5 Dormitory
Tehran Iran (Islamic Republic of) 14179-33791 +98 84 2442 3269 valinejad.vahid@gmail.com Tehran University of Medical Sciences scientific Vahid Valinejad
Enghelab square, kargar shomali Blvd, Borhany Alley, Enghelab 5 Dormitory
Tehran Iran (Islamic Republic of) 14179-33791 +98 84 2442 3269 valinejad.vahid@gmail.com Tehran University of Medical Sciences Iran (Islamic Republic of) Patient symptoms of non-fluent aphasia and aphasia quotient (AQ) between 51 to 75 on the test P-DAB-1 that represents the moderate aphasia Earn more than 50% on the subscales of Auditory Comprehension and Continuous Instructions on the P-DAB-1 test Agrammatic sentence production according to descriptive speech (Bird's Nest) and story retelling (three kids) in a way that speech is distorted and non-fluent; the percentage of sentences is reduced, and production of grammatical morphemes and verbs is reduced Difficulty in the verb tense inflection with less than 50 % in accuracy of regular and irregular verb tense inflection The ability to read in the subtest of single word reading in Bilingual Aphasia Test (BAT) Right-handed patient (using Edinburgh scale) Patients who are Persian monolingual or are fluent in Persian if they are bilingual Normal or near normal visual ability Normal or near normal hearing Minimum 9th grade education The patient has a stroke lesion on the left side of the brain, which last at least six months of its occurrence Aged between 18 - 65 years old 18 years 65 years Both History of neurological and psychological problems, speech and language problems, and learning problems Patients with apraxia Patients with Dysarthria in informal assessment Sign of claustrophobia Pregnant female subjects Subjects who have metal prosthesis R47.01 Aphasia Rehabilitation Intervention group: ACTION treatment will be performed on patients with agrammatic aphasia with a focus on verb learning and its tense inflection in sentence structure. The treatment steps are as follows: Stage 1 Syntactic Level: Recovery of nonverbal verbs in sentence context. a picture is shown with a sentence under it, in which the verb, in infinitival form, is left out.The participant reads the sentence (if necessary with the help of the therapist) and has to fill in the missing verb orally. Step 2: Syntactic-syntactic step: Retrieves the verb in the context of the sentence. As in step 1, but here the verb tense has to be inflected correctly . a picture is shown with a sentence under it, in which the verb, in infinitival form, is left out.The participant reads the sentence (if necessary with the help of the therapist) and has to fill in the missing verb orally. Step 3. Sentence construction: An image is shown to the participant and he or she must make a grammatical sentence. Trained and generalization verb tense inflection score. Timepoint: verb tense inflection assessment for 17 times: 3 baselines, 12 during treatment (once per week for 12 weeks), 14 and 30 days after treatment. Method of measurement: verb tense inflection assessment test. Trained and generalization sentence production score. Timepoint: sentence production assessment for 17 times: 3 baselines, 12 during treatment (once per week for 12 weeks), 14 and 30 days after treatment. Method of measurement: sentence production test. The place of the activated brain area. Timepoint: brain activation imaging 2 times: once pre-treatment and once after treatment. Method of measurement: functional magnetic resonance imaging. Sentence production score. Timepoint: sentence production assessment for 17 times: 3 baselines, 12 during treatment (once per week for 12 weeks), 14 and 30 days after treatment. Method of measurement: sentence production assessment test. Tehran University of Medical Sciences Approved 2019-10-22 Ethics committee of Tehran University of Medical Science Floor 13, Block A, Ministry of Health & Medical Education Headquarters, Between Zarafashan & South Falamak, Qods Town, Tehran, Iran. Tehran Tehran Iran (Islamic Republic of)