IRCT20180919041070N2 IRCT 2019-12-03 Iran University of Medical Sciences Adjuvant radiotherapy method in breast cancer. Comparison of short term results of IORT boost and hypofractionated EBRT after BCS with conventional whole breast radiotherapy and external boost in early breast cancers from 2019 to 2020 2019-11-16 anticipated 68 Complete https://irct.ir/trial/43648 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Breast cancer. Intervention 1: Intervention group: In hypofractionated radiotherapy group, during breast conservation surgery, patients will receive intraoperative electron radiation therapy with 10 gray dose. Postoperatively, patients will receive systemic treatment as required by the National Comprehensive Cancer Network Guidelines, including chemotherapy and Target Therapy. Following completion of this treatment, patients will receive whole breast hypofractionated radiotherapy in 16 sessions at a total dose of 42.56 Gy. Intervention 2: Control group: In conventional radiotherapy group, patients will receive external radiation therapy with total dose of 50 gray that will be followed by 10 gray extra dose to the tumor bed after breast conservation surgery with negative margin as well as chemotherapy and targeted therapy. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is As the study is being formulated, the researchers will comment on the decision after reviewing all aspects and obtaining consent from all patients.