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IRCT20190103042219N1 IRCT 2019-12-14 Islamic Azad University Effects of resistance training and curcumin on fatty liver Effects of resistance training and curcumin supplementation on the liver biochemical markers levels and structure in old women with non-alcoholic fatty liver disease 2016-10-22 anticipated 45 Complete https://irct.ir/trial/43788 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Each subject was assigned a code. The codes were given to an uninformed person who was also the master of the plan. The teacher found 45 randomly codes by using the Internet and assigned to each group, Blinding description: Subjects were identified using the code. Subjects were categorized by a unknown and groups has code. Only the code was given to the lab and the name of the subject and group was not specified. Only the code was given to the analysis. The supplement and placebo subjects were unaware of their group name. N/A Fatty liver. Intervention 1: Intervention group: Resistance training: 1-The warm-up consisted of working out with a fixed bike for 8 minutes and 5 minutes of light stretching exercises. 2- The nonlinear resistance training program used in this study has been proposed by Nikseresht et al. (Nikseresht et al., 2014). Each session took about 60-70 minutes for main training (plus about 20 minutes for warm-up and cool-down), three days a week (nonconsecutive) which lasted 12 weeks. Intervention 2: Intervention group: Curcumin supplement: Participants in supplement groups were asked to take one curcumin capsule (Curcumin 80 mg as Nanomicelle produced by Minoo Pharmaceutical Co.) per day after breakfast. Intervention 3: Intervention group: Resistance training with curcumin supplement. This group has curcumin supplementation plus non-liner resistance exercise training. Intervention 4: Control group: Plasebo. Has no exercise training and take one placebo capsule per day after breakfast for 12 weeks. Yes - There is a plan to make this available What will be shared: Liver enzyme When: 4 month To whom: Researchers Conditions: For article Where to obtain: Researcher How to obtain: Contact with researcher Comments:
public Mohammad Ali Azarbayjani
Sohanak
Tehran Iran (Islamic Republic of) 1955847781 0214460017 m_azarbayjani@iauctb.ac.ir Islamic Azad University scientific Mohammad Ali Azarbayjani
Sohanak
Tehran Iran (Islamic Republic of) 1955847781 +98 21 4460 0070 m_azarbayjani@iauctb.ac.ir Islamic Azad University Iran (Islamic Republic of) Being obese Elderly (60-71 years old) Female Having fatty liver disease Untrained 60 years 71 years Female Addiction to smoking Alcohol abuse Doing regular physical exercises in the last 6 months Having lung disease Kidney disease Cardiovascular disease Liver transplantation Estrogen intake High blood pressure Chronic disorders Taking special medications such as statins Having a special dietary program Allergy to curcumin Having a cancer K76.0 Fatty (change of) liver, not elsewhere classified Treatment - Other Treatment - Drugs Treatment - Drugs Placebo Intervention group: Resistance training: 1-The warm-up consisted of working out with a fixed bike for 8 minutes and 5 minutes of light stretching exercises. 2- The nonlinear resistance training program used in this study has been proposed by Nikseresht et al. (Nikseresht et al., 2014). Each session took about 60-70 minutes for main training (plus about 20 minutes for warm-up and cool-down), three days a week (nonconsecutive) which lasted 12 weeks. Intervention group: Curcumin supplement: Participants in supplement groups were asked to take one curcumin capsule (Curcumin 80 mg as Nanomicelle produced by Minoo Pharmaceutical Co.) per day after breakfast. Intervention group: Resistance training with curcumin supplement. This group has curcumin supplementation plus non-liner resistance exercise training. Control group: Plasebo. Has no exercise training and take one placebo capsule per day after breakfast for 12 weeks. Liver enzymes, including alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP). Timepoint: Blood samples were taken before the intervention and 48 hours after 8 weeks of training. Method of measurement: ALT, AST, ALP levels were measured by Pars Azmon Kit. Islamic Azad University Approved 2019-09-26 Islamic Azad University, Kazeroun Branch, Iran with ethical code: IR.IAU.KAU.REC.1398.079 Islamic Azad university Kazeroun Fars Iran (Islamic Republic of)