IRCT20191127045525N1 IRCT 2020-04-07 Shiraz University of Medical Sciences Probiotic applications in obesity and related mood disorders Effects of co-supplementation with probiotic and magnesium on components of microbiota-gut-brain axis including mood, intestinal barrier function and stool microbial populations in obese subjects with metabolic mood syndrome 2020-04-20 anticipated 90 Complete https://irct.ir/trial/43823 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: By implementing block randomization method using blocks of four, eligible subjects will be randomly allocated to either intervention or control group. Allocation concealment will be conducted by application of sealed envelopes containing active or placebo, created by a colleague that is not involved with data gathering and participant evaluation, Blinding description: All active capsules and placebo will be the same in size, color, odor, taste and other related characteristics. Furthermore, the packaging will be the same so neither data collectors and outcome assessors (that are the same in the present study) nor participants will be aware of the intervention type. 3 Obesity with mood disorders. Intervention 1: Intervention group will recieve 1 gram Capsule containing lactobacillus and bifidobacteria at dose of 3*10 9 CFU + one capsule containing 1 gram magnesium chloride providing 250 milligrams of elemental magnesium on a daily basis after one of main meals (preferably dinner). Intervention 2: Control group will receive two 1-gram capsules containing maldodextrin similar to those with active components based on color, shape, odor, weight, and packaging, on a daily basis after a main meal (preferably dinner). No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information