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IRCT20150417021806N5 IRCT 2020-08-30 Semnan University of Medical Sciences Effects of Ketorolac, Metoclopramide, Lidocaine on Reducing Pain During Propofol IV Injection Comparison of the Effects of Ketorolac, Metoclopramide, Lidocaine on Reducing Pain During Propofol IV Injection in general anesthesia induction 2019-12-22 anticipated 120 Complete https://irct.ir/trial/43908 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: We use classified quadratic permutation block to randomize the patients. All the patients are divided into 4 groups including men 18to34 years old, women 18to34 years old, men 35to50 years old and women 35to50 years old. Then blocked randomization is applied to each group separately, Blinding description: Blinding is applied to both patients and anesthesiologist who injects drugs and records the pain severity.The anesthesiologist is unaware of the type of the drugs and injects prefilled syringes; then he asks about the severity of pain and records the answers. The patient are unaware of the type of the drug ,too. 3 Pain During Propofol IV Injection in general anesthesia induction. Intervention 1: Control group: After injection of 2 cc water, 30 milligram Propofol is injected at the rate of 0.5cc per second. Intervention 2: Intervention group 1: After injection of 40 milligram Lidocain, 30 milligram Propofol is injected at the rate of 0.5cc per second. Intervention 3: Intervention group 2: After injection of 10 milligram Metoclopramide, 30 milligram Propofol is injected at the rate of 0.5cc per second. Intervention 4: Intervention group 3: After injection of 30 milligram Ketorolac, 30 milligram Propofol is injected at the rate of 0.5cc per second. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No further information
public Abolfazl Abdollahpoor
Kosar hospital, Amin Blvd, Golestan Town
Semnan Iran (Islamic Republic of) 3519899951 0098 23 31420 abolfazlabdollahpoor@semums.ac.ir Semnan University of Medical Sciences scientific Abolfazl Abdollahpoor
Kosar hospital, Amin Blvd, Golestan Town
Semnan Iran (Islamic Republic of) 3519899951 0098 23 31420 abolfazlabdollahpoor@semums.ac.ir Semnan University of Medical Sciences Iran (Islamic Republic of) patient 18-50 year old who candidate for elective surgery with ASA1 and ASA2 18 years 50 years Both sedative , analgesic or narcotic agents consumption within 24 hours before surgery analgesic or narcotic drugs or alcohol abuse contraindications of lidocain, metochlopramide, ketorolac or other NSAIDs contraindications of propofol including alleric reaction to foods such as egg or soy bean chronic pain disorders neurologic or psychiatric disorders pregnancy unable to communicate verbally G89.1 Acute pain, not elsewhere classified Placebo Other Other Other Control group: After injection of 2 cc water, 30 milligram Propofol is injected at the rate of 0.5cc per second Intervention group 1: After injection of 40 milligram Lidocain, 30 milligram Propofol is injected at the rate of 0.5cc per second. Intervention group 2: After injection of 10 milligram Metoclopramide, 30 milligram Propofol is injected at the rate of 0.5cc per second. Intervention group 3: After injection of 30 milligram Ketorolac, 30 milligram Propofol is injected at the rate of 0.5cc per second. Pain During Propofol IV Injection. Timepoint: Immediately after Propofol injection, before complete anesthesia, the severity of pain on injection is recorded. Method of measurement: Verbal Rating Scale. Semnan University of Medical Sciences Approved 2019-09-17 Ethics committee of Semnan University of Medical Sciences Kosar hospital, Amin Blvd, Golestan Town Semnan Semnan Iran (Islamic Republic of)