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IRCT20190215042716N1 IRCT 2020-01-11 Shahid Beheshti University of Medical Sciences Gastric residual volume evaluation with ultrasonography after intravenous ondansetron and metoclopramide and neostigmine :A Double Blind Randomized clinical Trial Gastric residual volume evaluation with ultrasonography after intravenous ondansetron and metoclopramide and neostigmine :A Double Blind Randomized clinical Trial 2019-08-22 anticipated 30 Complete https://irct.ir/trial/44062 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients who met the inclusion criteria were selected by random number table from left to right reading method. The numbers were between 00 and33 in group A (ondansetron) and patients with numbers between 33 and 66in group B (metoclopramide) and patients with numbers from 66 to99were divided into intervention group C (Neostigmine) . (Randomized Table is a set of numbers that are generated without a specific pattern and order in a completely random way and are tabulated. In order to use this table, the researcher must pre-determine the numbers to read and the default for the intervention group numbers), Blinding description: Patients and their legal guardians will first receive consent and patients will be included in the study, and this study will be conducted according to the ethical standards stated in the 1964 Helsinki Declaration. Then the patients and their legal counsel. It is explained that all drugs are common drugs in our treatment and our study examines their superiority over each other. The nurses will then give the patients a group of drugs that are perfectly matched in shape, color and packaging, and then sonographed by a intensive care physician who has no knowledge of the drug being administered and the remaining gastric volume measured. The information is then subdivided into three groups by the data analyzer and analyzed. 3 Gastric volume after gavage. Intervention 1: Intervention group 1: Ondansetron: Patients are given 8 mg intravenous ondansetron twice daily for 20 minutes and after five half-lives of medication their gastric volume is measured with sonography four consecutive days 3 hours after gavage. Intervention 2: Intervention group 2: Metoclopramide: Patients are given 10 mg intravenous metoclopramide infused three times daily for 20 minutes and after five half-lives of medication their gastric volume is measured with sonography four consecutive days 3 hours after gavage. Intervention 3: Intervention group3: Neostigmine: Patients are given 2.5 mg intravenous infusion neostigmine for 20 minutes once daily and after five half-lives of medication their gastric volume is measured with sonography four consecutive days 3 hours after gavage. Yes - There is a plan to make this available What will be shared: All potential data can be shared after unidentifiable people When: Start of access period from 1400 To whom: Researchers working in academic and scientific institutions Conditions: Help to research Where to obtain: navid_shafigh2005@yahoo.com How to obtain: Once the email has been sent and the email confirmation has been valid, the documentation will be sent to their email within one month. Comments:
public Navid Shafigh
Masih Daneshvari Hospital, Darabad Avenue, Shahid Bahonar roundabout, Tehran, Iran
Tehran Iran (Islamic Republic of) 1956944413 +98 21 2111 9279 navid_shafigh2005@yahoo.com Shahid Beheshti University of Medical Sciences scientific Navid Shafigh
Masih Daneshvari Hospital, Darabad Avenue, Shahid Bahonar roundabout, Tehran, Iran
Tehran Iran (Islamic Republic of) 1956944413 +98 21 2912 3100 navid_shafigh2005@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Patients 18 to 80 years Patients hospitalized in ICU Patients with nasogastric tube or percutaneous gastrostomy tube 18 years 70 years Both Do not place the nasal gastric tube in the stomach Prisoners Ileus Long-term fasting planning The remaining volume of the stomach is not examined by nurses for any reason K21.9 Gastro-esophageal reflux disease without esophagitis Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 1: Ondansetron: Patients are given 8 mg intravenous ondansetron twice daily for 20 minutes and after five half-lives of medication their gastric volume is measured with sonography four consecutive days 3 hours after gavage. Intervention group 2: Metoclopramide: Patients are given 10 mg intravenous metoclopramide infused three times daily for 20 minutes and after five half-lives of medication their gastric volume is measured with sonography four consecutive days 3 hours after gavage. Intervention group3: Neostigmine: Patients are given 2.5 mg intravenous infusion neostigmine for 20 minutes once daily and after five half-lives of medication their gastric volume is measured with sonography four consecutive days 3 hours after gavage. Size of gastric residual volume on ultrasound. Timepoint: Patients were studied after 5 half-lives of drug from the third day and 4 hours after morning gavage for the next 4 days. Method of measurement: Sonography device. Shahid Beheshti University of Medical Sciences Approved 2019-12-01 Ethics committee of Shahid Beheshti University of Medical Sciences and Health Services SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)