IRCT138903264196N1 IRCT 2013-01-19 Shiraz university of Medical Scienced Clinical & antimicrobial effect of iodine potassium iodide Comparison of clinical and antimicrobial efficacy of 2% IKI and 2.5% sodium hypochlorite irrigants in infected root canals- An in vivo study 2009-12-31 anticipated 30 Complete https://irct.ir/trial/4421 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 1-2 Chronic apical periodontitis. Intervention 1: Intervention group: After first antimicrobial sampling upon access ( S1), in this group irrigation was carried out with normal saline. Two milliliters of this solution were used to irrigate the canals after each instrument (10mL overall).Each canal was flushed with 2% IKI solution as final rinse for a period of 5 minutes. After inactivation of IKI with 2mL 5% sodium thiosulfate followed by 2mL normal saline, the second microbial sampling (S2) was performed.Subsequently, the canals were filled with gutta-percha and Tubli-Seal sealer (ZOE-based; SybronEndo, Orange, CA, USA) using cold lateral compaction technique. The tooth was temporized and permanent restoration was planned at the next visit.Moreover, the patients will follow-up after 30 months to evaluate the periapical healing of the teeth by clinical and radiological examinations. Intervention 2: Positive control group: After the first antimicrobial sampling upon access (S1), in this group irrigation was performed with 2 mL 2.5% NaOCl after each instrument (10mL overall).After instrumentation was completed, the canals were flushed with 2 mL 5% sodium thiosulfate followed by 2 mL normal saline and second microbial sampling (S2) was achieved by using 3 sterile paper cones. Subsequently, the canals were filled with gutta-percha and Tubli-Seal sealer (ZOE-based; SybronEndo, Orange, CA, USA) using cold lateral compaction technique. The tooth was temporized and permanent restoration was planned at the next visit. Moreover, the patient will follow-up 30 months after treatment to monitor the healing of periapical lesion by clinical and radilogical examinations.