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IRCT201111014203N2 IRCT 2011-11-22 Deputy of Research, Semnan University of Medical Sciences Efficacy of Glucosamine in knee osteoarthrosis Study the efficacy of Glucosamine phonophoresis in knee osteoarthrosis 2011-09-23 anticipated 36 Complete https://irct.ir/trial/4427 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. N/A Osteoarthrosis. Intervention 1: Intervention (3, Phonophoresis of glucosamine): Standard treatment (includes: IR, TENS and Exercise) with phonophoresis of glucosamine. Standard treatment includes: IR lasting for 20 minutes in distance of 40-50 cm from knees, TENS in form of high TENS (f=50-100 Hz, pulse time of 0/05 ms, low intensity level at tingling sensation), placing electrodes at knee joint line around the patella, for 15 minutes and SLR exercise, raising limb from the table at distance of 5 inches to strengthen quadriceps muscle. Ultrasound applied continuously, in combination of 50% gel and 50% glucosamine ointment, frequency of 1 MHz with the intensity of 2 watt/cm2 and duration of 5 minutes increasing gradually during the treatment sessions. For 10 sessions. Intervention 2: Intervention (2, Ultrasound): Standard treatment (includes: IR, TENS and Exercise) with US. Standard treatment includes : IR lasting for 20 minutes in distance of 40-50 cm from knees, TENS in form of high TENS (f=50-100 Hz, pulse time of 0/05 ms, low intensity level at tingling sensation), placing electrodes at knee joint line around the patella, for 15 minutes and SLR exercise, raising limb from the table at distance of 5 inches to strengthen quadriceps muscle. Ultrasound applied continuously, frequency of 1 MHz with the intensity of 2 watt/cm2 and duration of 5 minutes increasing gradually during the treatment sessions. For 10 sessions. Intervention 3: Intervention (1, Placebo US): Standard treatment (includes: IR, TENS and Exercise) with placebo US. Standard treatment includes: IR lasting for 20 minutes in distance of 40-50 cm from knees, TENS in form of high TENS (f=50-100 Hz, pulse time of 0/05 ms, low intensity level at tingling sensation), placing electrodes at knee joint line around the patella, for 15 minutes and SLR exercise, raising limb from the table at distance of 5 inches to strengthen quadriceps muscle. Placebo ultrasound for 5 minutes, around the knee joint. For 10 sessions.
public Dr. Atefeh Aminian Far
Kilometer 5 Damghan road, Semnan University of Medical Sciences
Semnan Iran (Islamic Republic of) 1439957181 +98 23 1335 4182 aminfar83@yahoo.com aminianfar@razi.tums.ac.ir Semnan University of Medical Sciences scientific Dr. Atefeh Aminian Far
Kilometer 5 Damghan road, Semnan University of Medical Sciences
Semnan Iran (Islamic Republic of) 1439957181 +98 23 1335 4182 aminfar83@yahoo.com aminianfar@razi.tums.ac.ir Semnan University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: presence of mechanical knee pain, osteophytes in knee X-ray, age above 50 years, morning stiffness lasting less than 30 minutes, crepitus in palpation of knee joint. Exclusion criteria: presence of other knee joint diseases, osteoarthrosis of hip and/or ankle joints, radicular pain originating from lumbar spine, physiotherapy history with intra/peri articular injection (corticosteroids or hyaluronic acid) during past six months, physiotherapy history during past six months, surgery history of knee joints, psychotic or mental disorders, neoplasm, infections, bleeding, neurologic disorders (sensory or motor) 50 years 75 years Female M15.4 Erosive (osteo)arthrosis Treatment - Other Treatment - Other Treatment - Other Intervention (3, Phonophoresis of glucosamine): Standard treatment (includes: IR, TENS and Exercise) with phonophoresis of glucosamine. Standard treatment includes: IR lasting for 20 minutes in distance of 40-50 cm from knees, TENS in form of high TENS (f=50-100 Hz, pulse time of 0/05 ms, low intensity level at tingling sensation), placing electrodes at knee joint line around the patella, for 15 minutes and SLR exercise, raising limb from the table at distance of 5 inches to strengthen quadriceps muscle. Ultrasound applied continuously, in combination of 50% gel and 50% glucosamine ointment, frequency of 1 MHz with the intensity of 2 watt/cm2 and duration of 5 minutes increasing gradually during the treatment sessions. For 10 sessions. Intervention (2, Ultrasound): Standard treatment (includes: IR, TENS and Exercise) with US. Standard treatment includes : IR lasting for 20 minutes in distance of 40-50 cm from knees, TENS in form of high TENS (f=50-100 Hz, pulse time of 0/05 ms, low intensity level at tingling sensation), placing electrodes at knee joint line around the patella, for 15 minutes and SLR exercise, raising limb from the table at distance of 5 inches to strengthen quadriceps muscle. Ultrasound applied continuously, frequency of 1 MHz with the intensity of 2 watt/cm2 and duration of 5 minutes increasing gradually during the treatment sessions. For 10 sessions. Intervention (1, Placebo US): Standard treatment (includes: IR, TENS and Exercise) with placebo US. Standard treatment includes: IR lasting for 20 minutes in distance of 40-50 cm from knees, TENS in form of high TENS (f=50-100 Hz, pulse time of 0/05 ms, low intensity level at tingling sensation), placing electrodes at knee joint line around the patella, for 15 minutes and SLR exercise, raising limb from the table at distance of 5 inches to strengthen quadriceps muscle. Placebo ultrasound for 5 minutes, around the knee joint. For 10 sessions. Quality of Life. Timepoint: Before treatment and after 10 treatment sessions . Method of measurement: WOMAC INDEX Questionaire. Duration of Morning stifness. Timepoint: Before treatment and after 10 treatment sessions . Method of measurement: Based on scale of 0-4. Measurement of resting and activity pain. Timepoint: Before treatment and after 10 treatment sessions . Method of measurement: Based on Visual Analogue Scale (0-10). Active range of motion of knee flexion. Timepoint: Before treatment and after 10 treatment sessions . Method of measurement: Based on Goniometery. Swelling of knee joint. Timepoint: Before treatment and after 10 treatment sessions . Method of measurement: Based on tape measurement. Deputy of Research, Semnan University of Medical Sciences Approved 2011-09-26 Deputy of Research, Semnan University of Medical Sciences Bassij Blvd, Semnan University of Medical Sciences, Deputy of Research, Semnan, Iran. Semnan Iran (Islamic Republic of)