IRCT20191222045853N1 IRCT 2020-02-06 Oroumia University of Medical Sciences The effects of nano-curcumin on obstructive pulmonary disease patients Investigating the effect of nano-curcumin supplementation on ventilatory capacity, polmonary function indices and serum interleukin-6 of patients with stage 3 (severe) and 4 (very severe) chronic obstructive pulmonary disease 2020-01-21 anticipated 60 Complete https://irct.ir/trial/44453 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Using the block randomization method. We have two case and control groups (C and T) that will have 6 models using 4 blocks (TTCC, TCTC, TCCT, CCTT, CTCT, CTTC). Subjects randomly will be assigned to case and control groups, Blinding description: Using coding on supplements. 3 chronic obstructive pulmonary disease. Intervention 1: Intervention group: nano-curcumin supplement, one capsule daily, each capsule contains 80 mg of curcumin in the form of nanomicelles, for 12 weeks, consumed with food, produced by Sina company. Intervention 2: Control group: Placebo, one capsule daily, each capsule consists of polysorbate, propylene glycol and distilled water for 12 weeks, consumed with food, produced by Sina company. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Release will be made but its exact schedule has not been determined yet. In future updates, information will be entered.