IRCT20191219045826N1 IRCT 2020-02-12 Shiraz University of Medical Sciences Effect of co2 gas in treatment of eye dark circle Evaluation of the effectiveness of Carboxytherapy in treatment of eye dark circle 2019-01-24 anticipated 20 Complete https://irct.ir/trial/44483 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Treatment. 4 Dark under eye circles. Twenty consecutive eligible patients with DECs selected to enter the study and received carboxytherapy as injection of once weekly intradermally 10 to 20 cc of CO2 gas at a rate of 20 cc per minute with angle of 15 degree to the orbital skin, for maximum 1 minute (usually few seconds), to appear skin swelling, erythema or occurrence of pain. The total number of therapies was 4 sessions with 1 week interval and patients followed 2 month later after last session of carboxytherapy. Patients were photographed by VisioFace® 1000 D - Courage - Khazaka Electronic.The data was recorded as quantitative values based on ΔE (the difference between pigmentation in different parts of pigmented orbit skin (lateral and middle and medial) with adjacent normal skin of extra-orbital area), which was calculated by VisioFace device. The name of carboxytherapy was carbocure and manufactured by ronak tajhiz ara in iran .Concentration of co2 gas was 99% .. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Participants are not happy with the publication.