IRCT20191010045051N1 IRCT 2020-05-30 Ahvaz University of Medical Sciences Evaluation of the topical effect of simvastatin on improving wound healing in diabetic patients Produce and evaluation of the topical effect of simvastatin cream 3% on improving wound healing in diabetic patients compared with placebo: In a randomized, triple -blind, placebo-controlled clinical trial phase 2 2020-04-04 anticipated 60 Complete https://irct.ir/trial/44880 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: The intervention group receives the cream containing simvastatin and the control group receives base cream (without simvastatin). Both groups receive standard treatment, Randomization description: Randomization is done by block method. Six-person blocks were designed including three patients receiving placebo and three patients receiving the drug.The form in the envelope was delivered to the Infectious Disease Physician. Patients, physician and analyzer will not know the group of formulation, Blinding description: The formulation of drug and placebo packaged in tubes with quite the same color and appearance. Patients, physician and analyzer will not know the group of formulation. 2 Diabetic foot ulcer. Intervention 1: Intervention group: Patients in this group twice daily for 4 weeks use 3% Simvastatin cream topically on diabetic foot ulcer.The product formulation is in the form of a cream with a absorbent base and Simvastatin powder has been purchased from Loghman Company. Intervention 2: Control group: Patients in this group twice daily for 4 weeks use the base cream(without simvastatin) topically on diabetic foot ulcer.The base cream has a completely similar formulation to the intervention group and only lacks Simvastatin. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I have not made a decision yet.