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IRCT20191231045965N1 IRCT 2020-03-08 Shahre-kord University of Medical Sciences Comparison the effects of silymarin and N-acetylcysteine on improvement of, Hepatic and renal Abnormalities in Patients with SeverePreeclampsia in post-partum Comparison the effects of silymarin and N-acetylcysteine on improvement of, Hepatic and renal Abnormalities in Patients with SeverePreeclampsia in post-partum 2020-03-19 anticipated 60 Complete https://irct.ir/trial/45002 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: First, our patient cohorts are characterized by the size of the sample set.Then they are randomized by simple randomization using randomization software and generating randomized codes to assign each patient to each of the groups under study.The code generated by the software is specified by the sample size of each group and which code the disease belongs to the researcher.Patients were included in the initial cohort, Blinding description: Both medicines are packaged in the same package and given to the resident and she will provide the medication at the prescribed time. 2 Preeclampcia. Intervention 1: Intervention group: 70 mg silymarin is given immediately after delivery and 12 hours and 24 hours after delivery. Intervention 2: Intervention group: 600 mg of N-acetylcysteine is given immediately after delivery, 12 hours and 24 hours after delivery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I will decide until the end of the study
public Leila Mahmoodnia
Nursery Street, Hajar Hospital
Shahre-kord Iran (Islamic Republic of) 8813833435 +98 38 3222 0016 leilamahmoodnia@yahoo.com Shahre-kord University of Medical Sciences scientific Leila Mahmoodnia
Nursery Street, Hajar Hospital
Shahre-kord Iran (Islamic Republic of) 8813833435 +98 38 3222 0016 leilamahmoodnia@yahoo.com Shahre-kord University of Medical Sciences Iran (Islamic Republic of) Maternal age is between 20 and 30 years. mothers BMI is between 20 and 24. Gestational age at termination of pregnancy is between 35 and 42 weeks. The patient's blood pressure should be greater than 140/90 mmHg before termination of pregnancy. Proteinuria, in urine random sample before pregnancy termination. Lack of history of hypertension, diabetes, kidney disease, collagen vascular disease and other cardiovascular diseases. The mother is nulipar and has no previous abortion or pregnancy. No history of smoking or alcohol in the mother. Pregnancy is single and not molar. Indication of termination of pregnancy in a patient with severe preeclampsia. The patient has complete consent to participate in the study and has signed the consent form. No incidence of eclampsia prior to inclusion. 20 years 30 years Female Patient dissatisfaction to participate in the study Patient with eclampsia O14.1 Severe pre-eclampsia Treatment - Drugs Treatment - Drugs Intervention group: 70 mg silymarin is given immediately after delivery and 12 hours and 24 hours after delivery. Intervention group: 600 mg of N-acetylcysteine is given immediately after delivery, 12 hours and 24 hours after delivery Liver enzymes. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: labratoary kit. Platlet count. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: count in mm3. Proteinuria. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: labratoary kit. Urea. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: mg per dl. Creatinine. Timepoint: 0,12,36 and 60 hours after intervention. Method of measurement: mg per dl. Blood pressure. Timepoint: q 3 hours in study. Method of measurement: mmHg. Number of blood pressure crisis in study. Timepoint: q 3 hours. Method of measurement: bp >160/110 mmhg. Shahre-kord university of medical Sciences Approved 2019-11-05 •Ethics committee of Shahrekord University of Medical Sciences No. 1,Godal cheshme Ave.,Gode pahlevanan Ave., Ayat Blvd., Shahrekord town Shahrekord Chahar-Mahal-va-Bakhtiari Iran (Islamic Republic of)