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IRCT138904064255N1 IRCT 2009-01-20 Tehran University of medical sciences Evaluating the effect of curcumin oral Gel on radiotherapy-induced mucositis Evaluating the effect of curcumin oral gel (curcuma longa) on radiotherapy-induced mucositis in patients with head and neck cancer 2009-01-20 anticipated 37 Complete https://irct.ir/trial/4519 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Single, Purpose: Treatment. 2-3 oral mucositis (radiotherapy-induced mucositis). Intervention 1: curcumin oral gel, 3 times a day, each time 5cc, keep in the mouth for a minute. Intervention 2: placebo oral gel, 3 times a day, each time 5 cc, keep in mouth for a minute.
public Dr. Arash Mansourian
Tehran university of medical sciences, Qods street, Keshavarz Blvd, Tehran, Iran
Tehran Iran (Islamic Republic of) +98 21 6611 2439 amansourian@sina.tums.ac.ir Tehran University of medical sciences, dental school scientific Dr. Arash Mansourian
Tehran university of medical sciences, Qods street, Keshavarz Blvd, Tehran, Iran
Tehran Iran (Islamic Republic of) +98 21 6611 2439 amansourian@sina.tums.ac.ir Tehran University of medical sciences, Dental school Iran (Islamic Republic of) Inclusion criteria: Patients older than 18 years, presence of head and neck cancer, minimum dose of radiation therapy 50 gy to induce mucositis, ability to use oral gel before radiotherapy session, signing informed consent Exclusion criteria: suffering from any kind of oral disease such as active oral infection, ulcer, receiving chemotherapy combined with radiotherapy, inability to use oral gel 18 years 100 years Both K13.7 Other and unspecified lesions of oral mucosa Treatment - Drugs Treatment - Drugs curcumin oral gel, 3 times a day, each time 5cc, keep in the mouth for a minute placebo oral gel, 3 times a day, each time 5 cc, keep in mouth for a minute Erythema. Timepoint: once a week during radiotherapy period. Method of measurement: milimeter. Oral mucositis grade. Timepoint: once a week during radiotherapy period. Method of measurement: clinical examination. Mouth burn. Timepoint: once a week during radiotherapy period. Method of measurement: visual analogue scale. Oral ulcer. Timepoint: once a week during radiotherapy period. Method of measurement: clinical examination. Side effects. Timepoint: once a week during radiotherapy period. Method of measurement: asking the patient. Tehran University of medical sciences Approved 2009-06-22 Ethics committee of Tehran university of medical sciences Vice-chancellor for Research, Tehran University of Medical Sciences, Qods street, Keshavarz Blvd-Tehran,Iran Tehran Iran (Islamic Republic of)