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IRCT20200122046216N1 IRCT 2020-02-10 Bojnourd University of Medical Sciences Compare the effect of TIVA and isoflurane on the activity of liver enzymes in patients undergoing laparoscopic cholecystectomy Compare the effect of TIVA and isoflurane on the activity of liver enzymes in patients undergoing laparoscopic cholecystectomy 2019-07-20 anticipated 30 Complete https://irct.ir/trial/45210 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Diagnostic, Randomization description: Patients' entry into this study will be a non-random sampling of "available" type. Then they will be divided into intervention and control groups randomly. The random number table will be used for the random specialization of the samples, Blinding description: The research will be a non-random sampling of the type "available" and then divided into two intervention groups as randomized block allocation using the web system. 2-3 Laparoscopic Cholecystectomy Surgery. Intervention 1: After the patient enters the operating room, the supine position extends over the operating room bed and is monitored initially. An oximeter probe and pressure gauge cuff are attached to the patient's hand and a ringer serum is provided to the patient. Midazolam (2 mg) and fentanyl (100 mcg) were administered in all patients. Atracurium (0.5 mg / kg) and propofol (2 mg / kg) are used to induce anesthesia. After 3 minutes of hyperventilating the patient and performing the intubation, isoflurane inhaler anesthetic of 1.2 mc is used to maintain anesthesia in the first group. Intervention 2: After the patient enters the operating room, the supine position extends over the operating room bed and is monitored initially. An oximeter probe and pressure gauge cuff are attached to the patient's hand and a ringer serum is provided to the patient. Midazolam (2 mg) and fentanyl (100 mcg) were administered in all patients. Atracurium (0.5 mg / kg) and propofol (2 mg / kg) are used to induce anesthesia. After 3 minutes hyperventilating the patient and performing the intubation, propofol intravenous anesthetic is administered in the anesthetic phase of 100 micrograms per kg body weight plus remifanil (0.1 micrograms per minute body weight). Yes - There is a plan to make this available What will be shared: After the end of the study some data and information will be loaded. When: 6 months after plan completion To whom: Universities and scientific institutes Conditions: Citing the source Where to obtain: Email to responsible and consent How to obtain: It will take up to two months for email to be answered. Comments:
public Mahdieh Dartomi
Shahriar Street - Bojnurd School of Nursing
Bojnurd Iran (Islamic Republic of) 74877-94149 +98 58 3229 7095 dartoomi1369m@gmail.com Bojnourd University of Medical Sciences scientific Mahdieh Dartomi
Bojnurd School of Nursing, Shahriar Street
Bojnurd Iran (Islamic Republic of) 74877-94149 +98 58 3229 7095 dartoomi1369m@gmail.com Bojnourd University of Medical Sciences Iran (Islamic Republic of) Has no history of anesthesia in the past 6 months The patient's age is between 18 and 70 years old According to the ASA class, there will be one or two classes of anesthesia 18 years 70 years Both The patient needs more medication during surgery Bleeding during surgery Laparoscopic change to laparotomy K81 Cholecystitis Treatment - Drugs Treatment - Drugs After the patient enters the operating room, the supine position extends over the operating room bed and is monitored initially. An oximeter probe and pressure gauge cuff are attached to the patient's hand and a ringer serum is provided to the patient. Midazolam (2 mg) and fentanyl (100 mcg) were administered in all patients. Atracurium (0.5 mg / kg) and propofol (2 mg / kg) are used to induce anesthesia. After 3 minutes of hyperventilating the patient and performing the intubation, isoflurane inhaler anesthetic of 1.2 mc is used to maintain anesthesia in the first group. After the patient enters the operating room, the supine position extends over the operating room bed and is monitored initially. An oximeter probe and pressure gauge cuff are attached to the patient's hand and a ringer serum is provided to the patient. Midazolam (2 mg) and fentanyl (100 mcg) were administered in all patients. Atracurium (0.5 mg / kg) and propofol (2 mg / kg) are used to induce anesthesia. After 3 minutes hyperventilating the patient and performing the intubation, propofol intravenous anesthetic is administered in the anesthetic phase of 100 micrograms per kg body weight plus remifanil (0.1 micrograms per minute body weight). Anesthesia by Tiva. Timepoint: Time to start anesthesia. Method of measurement: Mg / kg body weight. Isoflurane Anesthesia. Timepoint: Anesthesia maintenance time. Method of measurement: Mac Anesthetic Evaporator. ALT Liver Enzyme. Timepoint: Hepatic enzyme activity preoperatively and postoperatively and 24 and 48 hours postoperatively. Method of measurement: Biochemical Autoanalysis Device. AST Liver Enzyme. Timepoint: Hepatic enzyme activity preoperatively and postoperatively and 24 and 48 hours postoperatively. Method of measurement: Biochemical Autoanalysis Device. ALP Liver Enzyme. Timepoint: Hepatic enzyme activity preoperatively and postoperatively and 24 and 48 hours postoperatively. Method of measurement: Biochemical Autoanalysis Device. Bojnourd University of Medical Sciences Approved 2016-09-19 Ethics committee of North Khorasan of University of Medical Sciences Shahriar Street - Research Assistant Bojnurd North Khorasan Iran (Islamic Republic of)