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IRCT20190101042195N1 IRCT 2020-10-28 Mashhad University of Medical Sciences Effect of Probiotic in treatment of peri--implantitis Evaluation of the effect of topical administration (mouthwash) of capsuls containing probiotics in the treatment of patients with pre-implantitis (clinical trial) 2020-09-10 anticipated 70 Complete https://irct.ir/trial/45308 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block This method is used to prevent eye imbalance in the number of manufacturing companies that are assigned to each group. Block liquidation ensures that it is not approved at any time during the refund period, but can not be validated in other power groups, and if some of the companies in each group are equal, this method requires that each block be specified. (Types of quadruple blocks). Then write the list of blocks and assign the numbers (AABB (1) - ABAB (2) -ABBA (3) -BBAA (4) - BABA (5) - BAAB (6) after selecting random numbers between one and 6 (Eg 1 4 5, etc.) and finally it is determined that it cures the specified list before (ad AABB-BBAA-BABA-).} The concealment is sealed envelope, Blinding description: Origin researcher and analyzer and patient are unaware of control and intervention groups. 3 Peri-implantitis. Intervention 1: Intervention group: Patients are scaled and given capsules of a pre-coded form (for two weeks and once a day). The intervention group is given 14 capsules containing probiotics, brand Gerilact. every night Dissolve one capsule in two tablespoons of warm water and hold it in the mouth as a mouthwash for one to two minutes and then take it out. Patients are re-evaluated after the first examination, 14 days after the first examination and 30 days after the first examination. Intervention 2: Control group: Patients are scaled and 14 capsules of one form and pre-coded placebo are given for two weeks and once a day. Every night, the contents of one capsule are dissolved in two tablespoons of lukewarm water and mouthwash for one to two minutes and then taken out. 14 days and 30 days after the first examination ,Will be re-evaluated. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Naser Sargolzaei
Mashhad Dental School , Vakilabad Blvd
Mashhad Iran (Islamic Republic of) 9177948959 +98 51 3806 7000 sargolzaein@mums.ac.ir Mashhad University of Medical Sciences scientific Naser Sargolzaei
Mashhad Dental School , Vakilabad Blvd
Mashhad Iran (Islamic Republic of) 9177948959 +98 51 3806 7000 sargolzaein@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Age 30-60 years Preimplantitis index Do not allergy to probiotics 30 years 60 years Both K05.6 Diseases of oral cavity, salivary glands and jaws, Periodontal disease, , unspecified Treatment - Drugs Placebo Intervention group: Patients are scaled and given capsules of a pre-coded form (for two weeks and once a day). The intervention group is given 14 capsules containing probiotics, brand Gerilact. every night Dissolve one capsule in two tablespoons of warm water and hold it in the mouth as a mouthwash for one to two minutes and then take it out. Patients are re-evaluated after the first examination, 14 days after the first examination and 30 days after the first examination. Control group: Patients are scaled and 14 capsules of one form and pre-coded placebo are given for two weeks and once a day. Every night, the contents of one capsule are dissolved in two tablespoons of lukewarm water and mouthwash for one to two minutes and then taken out. 14 days and 30 days after the first examination ,Will be re-evaluated Measure the depth of the pocket around the implant. Timepoint: Measure the depth of the pocket at the beginning of the study and 14,30 days after the start of probiotic use. Method of measurement: probe. Mashhad University of Medical Sciences Approved 2020-06-27 Ethics committee of Mashhad University of Medical Sciences Mashhad Dentistry School,Vakilabad Blvd Mashhad Razavi Khorasan Iran (Islamic Republic of)