IRCT201208144269N4 IRCT 2012-10-10 Vice Chancellor for Research, Tabriz University of Medical Sciences Comparative efficacy of Tacrolimus ointment versus Calcipotriol ointment in vitiligo Comparative efficacy of 0.1%Tacrolimus ointment versus 0.005% Calcipotriol ointment in perifollicular pigmentation in patients with hand and facial vitiligo 2012-11-29 anticipated 70 Complete https://irct.ir/trial/4535 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: The patients will be randomized into group A or B, using table of random numbers and the software RAND list. The ointments will be provided in plastic containers. Code A or B will be used for the containers. The physician, who will assess the patients monthly, will be different than the one who will prescribe the ointments to the patients at the baseline of the trial. Thus, the study will be double blinded. 2-3 Vitiligo. Intervention 1: Tacrolimus ointment (0.1%) manufactured by "Quality Care" which will be rubbed on the lesions once every night for one year. The weekly dosage used will be less than 100 grams. Intervention 2: Calcipotriol ointment (0.005%) with the trade name of "Daivonex" manufactured by "Quality Care" which will be rubbed on the lesions once every night for one year. The weekly dose of the ointment will be less than 100 grams to avoid probable hypercalcemia.