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IRCT20200115046150N1 IRCT 2020-09-12 Vice Chancellor for Research, Alborz University of Medical Sciences cycloserine effect on neuropathic pain decreasing Assessment of cycloserine effect on neuropathic pain after lumbar disc herniation surgery 2020-03-20 anticipated 70 Complete https://irct.ir/trial/45407 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, a simple random method based on a single sequence of Random allocations have been used. A table of random numbers has been used for this purpose, Blinding description: In this study, participants included the main researcher, health care personnel (physicians, nurses) who are responsible for patient care, and data collection officials regarding the type of drugs given to patients and also in which group each person Are blind. 2-3 Lumbar disc herniation. Intervention 1: Intervention group: Cycloserine 250 g capsules are given to all members of the intervention group 2 hours before the start of surgery orally and in a single dose. Intervention 2: Control group:The whole group of patients in the control group is given a dose of capsule filled of Rice powder and the volume and weight of the drug are the same as in the intervention group 2 hours before the start of surgery. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I have not decided yet
public Pouria Basiry
Alborz University of Medical Sciences, Administrative Town, North Taleghani Boulevard, Taleghani Square, Karaj
Karaj Iran (Islamic Republic of) 3149779453 +98 26 3256 3324 pouriabasiry@gmail.com Alborz University of Medical Sciences scientific Pouria Basiry
Alborz University of Medical Sciences, Administrative Town, North Taleghani Boulevard, Taleghani Square, Karaj
Karaj Iran (Islamic Republic of) 3149779453 +98 26 3255 8920 pouriabasiry@gmail.com Alborz University of Medical Sciences Iran (Islamic Republic of) Age 18-70 years old BMI 19-24 Having informed consent Adaptation of clinical signs and symptoms to imaging findings 18 years 70 years Both Candidate patients for laminectomy discectomy G55.1 Nerve root and plexus compressions in intervertebral disc disorders Treatment - Drugs Placebo Intervention group: Cycloserine 250 g capsules are given to all members of the intervention group 2 hours before the start of surgery orally and in a single dose. Control group:The whole group of patients in the control group is given a dose of capsule filled of Rice powder and the volume and weight of the drug are the same as in the intervention group 2 hours before the start of surgery. Lumbar pain. Timepoint: 6,12,18,24 hours post operation. Method of measurement: visual analogue scale. Morphine intake. Timepoint: 6,12,18,24 hours post operation. Method of measurement: The volume of drug injected into the cc. Vice Chancellor for Research, Alborz University of Medical Sciences Approved 2020-08-24 Ethics committee of Alborz University of Medical Sciences Office of the Ethics Committee, Second Floor, Deputy of Research and Technology, Saffarian Alley, 45 Golshahr Street, Karaj Karaj Alborz Iran (Islamic Republic of)