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IRCT20120708010210N9 IRCT 2020-04-10 Shiraz University of Medical Sciences The Comparison of Two Protocols for Treatment of Infertility The Comparison of the GnRH Agonist-Antagonist Protocol (AAP) with GnRH Antagonist Protocol in Women with Poor Ovarian Response in Assisted Reproduction Technique (ART) during Controlled Ovarian Hyper Stimulation Cycles 2019-04-14 anticipated 80 Complete https://irct.ir/trial/45469 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization is performed using the block method and Random Allocation Software version 2 will be used in the preparation of 4-case blocks. The drugs in both groups are packaged and numbered in similar vials apparently by a researcher who is not involved in patient selection and follow-up, Blinding description: The clinical investigators (in direct contact with the patient), and participants will not be aware of the distribution of the drugs in the groups (double blinded), so that they are unaware of the content and dosage of the prescribed medication, and the medications will be similar in appearance. 2 Female infertility. Intervention 1: Intervention group: GnRH antagonist (Cetrotide, 0.25 mg SQ) with gonadotropin (225 units of gonadal F and 3 HMG ampoules) until artificial insemination. Intervention 2: Control group: GnRH antagonist (Cetrotide, 0.25 mg SQ) and continuing treatment without gonadotropin until artificial insemination. Yes - There is a plan to make this available What will be shared: Information about main outcomes of the study When: Six months after publishing the results To whom: Researchers in universities and scientific and research centers Conditions: In order to improve the treatment of infertility and subsequent researches and with the permission of the authors Where to obtain: Department of Obstetrics and Gynecology of Shiraz university of medical sciences How to obtain: Sending the request in writing or by email to the authors Comments:
public Parisa Keshtkaran
Hazrat Zeinab Hospital, Sibuyeh blvd.
Shiraz Iran (Islamic Republic of) 71538-13311 +98 71 3726 6812 parisa_18_k@yahoo.com Shiraz University of Medical Sciences scientific Afsoon Zarei
Hazrat Zeinab Hospital, Sibuyeh blvd.
Shiraz Iran (Islamic Republic of) 71538-13311 +98 71 3726 6812 zareia@sums.ac.ir Shiraz University of Medical Sciences Iran (Islamic Republic of) Age between 18 and 42 years All patients fulfill the Bologna criteria 18 years 42 years Female Presence of the specimen of TESE (Testicular Sperm Extraction) Endometriosis stage 3 and 4 N97 Female infertility Treatment - Drugs Treatment - Drugs Intervention group: GnRH antagonist (Cetrotide, 0.25 mg SQ) with gonadotropin (225 units of gonadal F and 3 HMG ampoules) until artificial insemination Control group: GnRH antagonist (Cetrotide, 0.25 mg SQ) and continuing treatment without gonadotropin until artificial insemination Clinical pregnancy rate. Timepoint: Two months after embryo transfer. Method of measurement: Vaginal sonography. Chemical pregnancy rate. Timepoint: Fourteen days after embryo transfer. Method of measurement: Pregnancy Test. Shiraz University of Medical Sciences Approved 2019-12-15 Ethics committee of Shiraz University of Medical Sciences Faculty of medicine, Zand Avenue Shiraz Fars Iran (Islamic Republic of)