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IRCT20200203046356N1 IRCT 2020-03-01 Zahedan University of Medical Sciences The effect of pomegranate mouthwash comparative evaluation of the effect of pomegranate mouthrinse and chlorohexidine mouthrinse on severe chronic periodontitis treatment 2019-12-22 anticipated 48 Complete https://irct.ir/trial/45572 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: The block randomization method is used and 48 closed envelopes are provided. People randomly select and open one. Of the 48 envelopes, 12 envelopes will be assigned to each of the A groups of placebo, B of pomegranate skin mouthwash, C of pomegranate seed mouthwash and D of chlorhexidine of 0.12%, Blinding description: The envelopes containing the mouthwash codes are kept with the secretary and the mouthwashes containing physiological serum, pomegranate skin mouthwash and pomegranate seed mouthwash and chlorhexidine mouthwash are packed in similar containers and in groups (A) and (B) And (C) and (D) are named and coded. The codes for each container for the patient are unknown to the researcher and will be kept confidential until the end of the study by the supervisor. 3 Chronic periodontitis. Intervention 1: Control group: Physiological serum (placebo) is used twice a day for 1 minute to 1 month to wash the mouth. Intervention 2: Intervention group: Pomegranate peel mouthwash is used twice a day for 1 minute to 1 month to wash mouth. Intervention 3: Intervention group: Pomegranate seed mouthwash is used twice a day for 1 minute to 1 month to wash the mouth. Intervention 4: Intervention group: Chlorhexidine 0.12% mouthwash is used twice a day for 1 minute to 1 month to wash the mouth. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is lack of time and Money
public Sanaz Isar
Azadegan Shargi St.
Zahedan Iran (Islamic Republic of) 9817699693 +98 54 3341 5705 Arbabi.Parvin@zaums.ac.ir Zahedan University of Medical Sciences scientific Parvin Arbabi Kalati
Azadegan Shargi St.
Zahedan Iran (Islamic Republic of) 9817699693 +98 54 3244 1814 Arbabi.Parvin@zaums.ac.ir Zahedan University of Medical Sciences Iran (Islamic Republic of) Patients Referred to Zahedan Dental School No previous treatment of periodontitis No antibiotic use in the past 6 months Lack systemic diseases affecting the periodontium No corticosteroids use Non-pregnancy and lactation No smoking chronic severe periodontitis(clinical attachment loss more than 5 mm) measured by the Williams probe 18 years no limit Both If the patient consumes pomegranate or pomegranate products (such as pomegranate juice) or other mouthwash other than as prescribed during the study period, the patient will be excluded. unwillingness to participate in further study K05.3 Chronic periodontitis Placebo Treatment - Drugs Treatment - Drugs Treatment - Drugs Control group: Physiological serum (placebo) is used twice a day for 1 minute to 1 month to wash the mouth. Intervention group: Pomegranate peel mouthwash is used twice a day for 1 minute to 1 month to wash mouth. Intervention group: Pomegranate seed mouthwash is used twice a day for 1 minute to 1 month to wash the mouth. Intervention group: Chlorhexidine 0.12% mouthwash is used twice a day for 1 minute to 1 month to wash the mouth. Depth of envelope. Timepoint: After 2 weeks, 1 month and 3 months of starting use of mouthwash. Method of measurement: By Williams Probe. MODIFIED GINGIVAL INDEX. Timepoint: After 2 weeks, 1 month and 3 months of starting use of mouthwash. Method of measurement: By clinical examination. SULCUS BLEEDING INDEX. Timepoint: After 2 weeks, 1 month and 3 months of starting use of mouthwash. Method of measurement: By clinical examination. Zahedan University of Medical Sciences Approved 2020-01-26 Ethics Committee of Zahedan University of Medical Sciences Dr. Hasabi Square, Zahedan University of Medical Sciences Zahedan Sistan-va-Balouchestan Iran (Islamic Republic of)