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IRCT20200205046384N1 IRCT 2020-05-09 Ahvaz University of Medical Sciences investigating the effect of pomegranate extract in asthma Evaluating the effect of pomegranate extract on some serum immunologic factors(IL-35، hs-CRP), oxidative stress status (PAB) and spirometry test in patients with persistent allergic asthma with mild and moderate severity 2020-04-20 anticipated 64 Complete https://irct.ir/trial/45612 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The participants will be randomized through the statistical method of permuted block. Blocks will be determined using statistical software, Blinding description: The researcher and participants are blinded by coding the drug in the form of A and B, so that someone else is asked to encode the pomegranate extracts and placebo to A and B which are similar in appearance. The participants and the researcher will be uninformed of the type of intervention. As a result, the study will be performed in the forms of double blind. 2-3 Asthma. Intervention 1: Intervention group: group receiving pomegranate extract 500 mg / day in capsule form (two 250 mg capsules daily). Drug production center: The institute of medicinal plants research of Jahad Daneshgahi. The duration of drug use is 8 weeks. Intervention 2: Control group: Placebo-receiving group: Two capsules daily containing 250 mg toasted flour . Drug Production Center: The institute of medicinal plants research of Jahad Daneshgahi. The duration of drug use is 8 weeks. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information.
public Zainab Shateri
Nutrition Department,Faculty of Paramedicine, Ahvaz Jondishapour University of Medical Sciences, Golestan Blvd
Ahvaz Iran (Islamic Republic of) 6135715794 0098613311 shateri.z@ajums.ac.ir Ahvaz University of Medical Sciences scientific Zainab Shateri
Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Golestan Blvd
Ahvaz Iran (Islamic Republic of) 6137515794 0098613311 shateri.z@ajums.ac.ir Ahvaz University of Medical Sciences Iran (Islamic Republic of) Ages 18 to 65 years Patients with mild to moderate persistent allergic asthma, Forced Expiratory Volume in First Second(FEV1) greater than 60% Body mass index(BMI):18.5-30 Both sexes 18 years 65 years Both smoking Diabetes Pregnancy and lactation Autoimmune diseases Malignancies Digestive, liver or kidney problems Pneumonia Other pulmonary diseases Antioxidant usage blood pressure-lowering drugs  (Statin and ACE Inhibitors) J45.0 آسم Treatment - Drugs Placebo Intervention group: group receiving pomegranate extract 500 mg / day in capsule form (two 250 mg capsules daily). Drug production center: The institute of medicinal plants research of Jahad Daneshgahi. The duration of drug use is 8 weeks. Control group: Placebo-receiving group: Two capsules daily containing 250 mg toasted flour . Drug Production Center: The institute of medicinal plants research of Jahad Daneshgahi. The duration of drug use is 8 weeks. Prooxidant-antioxidant balance. Timepoint: at the beginning of the study and 8 weeks after the intervention. Method of measurement: Based on blood test using calorimetry. Forced Vital Capacity(FVC)/Forced Expiratory Volume in First Second(FEV1)، FEV1، FVC. Timepoint: at the beginning of the study and 8 weeks after the intervention. Method of measurement: Based on the result of the spirometer- Variable scale: percent. High sensitivity C-reactive protein (hsCRP). Timepoint: At the beginning of the study and 8 weeks after intervention. Method of measurement: Laboratory measurement (quantitative luminescence) - mg / dl. Blood pressure. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Based on the results of the Easy Life aneroid Sphygmomanometer-mmHg. Clinical variables and general patient status. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Based on a questionnaire filled by a specialist physician. IL-35. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Based on laboratory measurements-pg/ml. Complete blood cell count and differential count. Timepoint: At the beginning of the study and 8 weeks after the intervention. Method of measurement: Based on laboratory measurement. Ahvaz University of Medical Sciences Approved 2020-02-21 Research Ethics Committee of Ahvaz Jondishapour University of Medical Sciences Nutrition dep, faculty of Paramedicine, Ahvaz Jondishapour University of Medical Sciences, Golestan Highway, Ahvaz Town Ahvaz Khouzestan Iran (Islamic Republic of)