]>
IRCT20200201046326N1 IRCT 2020-07-03 The University of Mohaghegh Ardabili The effect of different genotypes of adiponectin gene on diabetes response to exercise Survey on the synergistic effect of some adiponectin gene polymorphisms in response to aerobic training with two different intensities in middle-aged men with type 2 diabetes 2019-08-22 anticipated 300 Complete https://irct.ir/trial/45713 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Supportive, Randomization description: First, the total sample size of 150 people after screening was determined as the research sample, then using random allocation method, 50 balls were considered for the first intervention group, 50 balls for the second intervention group and another 50 balls for the control group. These balls were placed in a lottery container, then balls were randomly removed from the container without replacement and the sequence created was recorded. N/A Type 2 Diabetes. Intervention 1: Intervention group 1: In this group, 50 diabetic patients perform low intensity aerobic exercise (65% of maximal oxygen consumption) for 12 weeks, 3 sessions per week. The content of a training session will include dynamic stretching movements in the warm-up (10 minute) and cool-down (7 minute) sections and Jogging for the main section (10 minute).The intensity and type of exercises are designed according to the standards and recommendations of the American College of Sports Medicine. Intervention 2: Intervention group 2: In this group, 50 diabetic patients perform high intensity aerobic exercise (80% of maximal oxygen consumption) for 12 weeks, 3 sessions per week. The content of a training session will include dynamic stretching movements in the warm-up (10 minute) and cool-down (7 minute) sections and Jogging for the main section (10 minute). The intensity and type of exercises are designed according to the standards and recommendations of the American College of Sports Medicine. Intervention 3: Control group: 50 diabetic patients who will not have regular exercise for 12 weeks. Yes - There is a plan to make this available What will be shared: Part of the data related to the distribution of the 5 polymorphisms studied will be shared. When: Start of access period 6 months after publication of Results To whom: Researchers working in academic and scientific institutions Conditions: Researchers in this field who have a larger statistical sample than our research Where to obtain: Elaheh Mamashli, PhD student of Mohaghegh Ardabili University, Mamashli.elahe@gmail.com 09115327323 How to obtain: After receiving the request, the data will be sent after informing the other participants in this research Comments:
public Elahe Mamashli
University of Mohaghgegh Ardabili, University Street
Ardabil Iran (Islamic Republic of) 5619911367 +98 17 3522 9933 mamashli.elahe@gmail.com The University of Mohaghgegh Ardabili scientific Elahe Mamashli
Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, University Street, Ardabil
Ardabil Iran (Islamic Republic of) 5619911367 +98 17 3522 9933 Mamashli.elahe@gmail.com The University of Mohaghegh Ardabili Iran (Islamic Republic of) All diabetic patients who have more than 12 years history of diabetes Hemoglobin A1c above 7 Age under 65 years old 45 years 65 years Male People with a history of cardiovascular disease and cancer Diabetic foot ulcer Having an amputation Severe retinopathy Having neurological and orthopedic disorders Having regular physical activity for the past 6 months E11 Type 2 diabetes mellitus Lifestyle Lifestyle Lifestyle Intervention group 1: In this group, 50 diabetic patients perform low intensity aerobic exercise (65% of maximal oxygen consumption) for 12 weeks, 3 sessions per week. The content of a training session will include dynamic stretching movements in the warm-up (10 minute) and cool-down (7 minute) sections and Jogging for the main section (10 minute).The intensity and type of exercises are designed according to the standards and recommendations of the American College of Sports Medicine. Intervention group 2: In this group, 50 diabetic patients perform high intensity aerobic exercise (80% of maximal oxygen consumption) for 12 weeks, 3 sessions per week. The content of a training session will include dynamic stretching movements in the warm-up (10 minute) and cool-down (7 minute) sections and Jogging for the main section (10 minute). The intensity and type of exercises are designed according to the standards and recommendations of the American College of Sports Medicine. Control group: 50 diabetic patients who will not have regular exercise for 12 weeks. Adiponectin. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Adiponectin ELISA kit. Five polymorphisms of the adiponectin gene. Timepoint: Before 12 weeks of aerobic exercise. Method of measurement: DNA extraction and pcr method. Hemoglobin A1c. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Using the HbA1c kit and the enzyme method (Diazyme). Fasting blood sugar. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Quantitative diagnostic kit (glucose oxidase), by enzymatic photometric method. Low-density lipoprotein(LDL). Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Relevant diagnostic kit, Enzymatic method. High-density lipoprotein (HDL). Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Relevant diagnostic kit, Enzymatic method. Total Cholesterol. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Relevant diagnostic kit, Enzymatic method. Triglycerides. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Relevant diagnostic kit, Enzymatic method. Blood pressure. Timepoint: Before and after 12 weeks of aerobic exercise. Method of measurement: Using a mercury sphygmomanometer. Ardabil University of Medical Sciences The University of Mohaghegh Ardabili Ardabil University of Medical Sciences Approved 2019-03-02 Ethics Committee in Biomedical Research of Ardabil University of Medical Sciences Research Ethics Committee, North side of Ardebil University of Medical Sciences, University Square, University Street Ardabil Ardabil Iran (Islamic Republic of)