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IRCT20191218045795N4 IRCT 2020-05-03 Sanandaj University of Medical Sciences Efficacy of Thiamine in Amnisia due to Electro Convulsive Therapy Sanandaj Thiamine study Effectiveness of Thiamine on Cognitive Performance of Paitients Under Electro-Convulsive Therapy: A Randomized Double Blind Clinical Trial. 2020-02-29 anticipated 70 Complete https://irct.ir/trial/45732 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: The random assignment of patients is done by the resident implementing the plan using pre-determined envelopes. The random allocation list is provided to the pharmacist by the block method provided by the methodological consultant. Required drugs are embedded in envelopes and numbered. Can be arranged in order to be given to patients. The drugs will be administered in two groups and will be similar in appearance. Wounded Patients who are evaluating outcomes, being a patient psychiatrist, will not be aware of grouping. Quadratic random blocking is also used for random allocation as follows: The 4-way random blocking method is as follows and its blocks include: AABB 1 For Group A patients And for Group B patients  BABA BBAA ABAB AABB ABBA BAAB BABA BABA ABBA BBAA AABB BABA ABAB BAAB                 BBAA 2 ABAB 3 BABA 4 ABBA 5 BAAB 6, Blinding description: Patients (participants) and outcome assessors, project researchers, patient therapist psychiatrists, and nurse staff who give medication were kept blind in the study. 3 Schizophrenia,Schizoaffective,Mood dosorders and Obsessive-compulsive disorders. Intervention 1: Intervention group: Thiamine 100 mg capsul Twice a day(morning & night) in the intervention group. Intervention 2: Intervention group:. Yes - There is a plan to make this available What will be shared: participant individual data When: 6 months after publication To whom: people working in academic institutions Conditions: After completing the study, it will be determined Where to obtain: email: nshamsalizadeh@yahoo.com How to obtain: 3 montj Comments:
public Narges Shamsalizadeh
Pasdaran
Sanandaj Iran (Islamic Republic of) 6617794795 +98 912 159 9112 n.shamsalizadeh@muk.ac.ir Sanandaj University of Medical Sciences scientific Narges Shamsalizadeh
Pasdaran
Sanandaj Iran (Islamic Republic of) 6617794795 +98 912 159 9112 n.shamsalizadeh@muk.ac.ir Sanandaj University of Medical Sciences Iran (Islamic Republic of) Patients candicate for ECT ; Age between 18-60 years old. The Patient or his or her legal guardian must sign the informed consent form. The number of Electro Convulsive Therapy sessions ; must be between 2-12 sessions. 18 years 60 years Both Alcohol and substance dependence except Caffeine and Nicotine in past 3 months. Proven Intelligent Disability or diagnosed with assistant. History of Delirium, Dementia and Cognitive Disorders. History of Thiamine consumption from 3 months before the visit. History of Thiamine sensitivity. F20,,F25,, Schizophrenia ,Schizoaffective disorder.Bipolar affective disoeder.Obssessive_compulsive disorder,Mood disorder(manic episode).Mood disorder(Depressive episode) Prevention Placebo Intervention group: Thiamine 100 mg capsul Twice a day(morning & night) in the intervention group Intervention group: Memory. Timepoint: 1day before begining and after ending the Electro Convulsive Therapy. Method of measurement: wechsler. Memory. Timepoint: 1day before begining and after ending the Electro Convulsive Therapy. Method of measurement: mini mental status examination. Tremor. Timepoint: During the intervention. Method of measurement: Patient Self Report. Cofusion. Timepoint: During the intervention. Method of measurement: Patient Self Report. Headache. Timepoint: During the intervention. Method of measurement: Patient Self Report. Nausea. Timepoint: During the intervention. Method of measurement: Patient Self Report. Sanandaj University of Medical Sciences Approved 2020-03-15 Ethics committee of kurdistan University of Medical Sciences Pasdaran blv,Sanandaj Sanandaj Kurdistan Iran (Islamic Republic of)