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IRCT20141217020351N12 IRCT 2020-12-06 Tehran University of Medical Sciences Evaluation of pregnancy outcomes in IVF cycles with uterine support with progesterone, Prolotex, and Cyclogest in the infertility center. Evaluation of pregnancy results in IVF cycles with luteal phase support with progesterone, prolotex, and Cyclogest in infertility center. 2019-08-06 anticipated 309 Complete https://irct.ir/trial/45786 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization is performed to one of three treatment groups with an equal number of patients using a random number table; In the order that we look from the top to the bottom of the table and patients enter the study randomly and in the order of the random number table; So that the researcher touches one of the numbers and then moves in the specified direction and records the numbers and assigns them to different groups. Patients in the first group, 1-100, the second group, 101-200, and the third group, 201-309, receive progesterone, Cyclogest, and Prolotex, respectively. 4 Types of female infertility. Intervention 1: Intervention group:In the first group; To transfer the frozen fetus on the second day of menstruation, 2 mg of Estradiol Valerate tablets are given three times a day for 9 days, and if there is an endometrium with a thickness of more than 7 mm, 100 mg of progesterone ampoule daily until 12 weeks of pregnancy is prescribed. Intervention 2: Intervention group:In the second group; To transfer the frozen fetus on the second day of menstruation, 2 mg Estradiol Valerate tablets are given three times a day for 9 days, and if there is an endometrium with a thickness of more than 7 mm, a Cyclogest suppository 400 mg twice a day for up to 12 weeks of Pregnancy is prescribed. Intervention 3: Intervention group:In the third group; To transfer the frozen fetus on the second day of menstruation, 2 mg Estradiol Valerate tablets are given three times a day for 9 days. If there is an endometrium with a thickness of more than 7 mm, Prolotex 25 mg daily, subcutaneously for up to 12 weeks of Pregnancy is prescribed. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Observing the confidentiality of patients.
public Maedeh Ahmadi Dastjerdi
Keshavarz Blvd, Imam Khomeini Hospital Complex,Vali-Asr Infertility Clinic.
Tehran Iran (Islamic Republic of) 1419733141 +98 21 6693 9320 dr.maedeh_ahmadi@yahoo.com Tehran University of Medical Sciences scientific Maedeh Ahmadi Dastjerdi
Keshavarz Blvd, Imam Khomeini Hospital Complex,Vali-Asr Infertility Clinic.
Tehran Iran (Islamic Republic of) 1419733141 +98 21 6693 9320 dr.maedeh_ahmadi@yahoo.com Tehran University of Medical Sciences Iran (Islamic Republic of) Infertile women aged 18 to 42 years BMI less than 30 Having less than three IVF cycles FSH < 15 U/L Estradiol less than 80 pg / ml Having a normal uterine cavity on a recent hysteroscopy, sonohistogram, or hysterosalpingogram 18 years 42 years Female Intramural fibroids deforming the uterine cavity Endometriosis stage three and four Hydrosalpinx History of poor response to treatment Spontaneous abortion Adrenal disease Thyroid disease Thromboembolic diseases N97.9 Female infertility, unspecified Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group:In the first group; To transfer the frozen fetus on the second day of menstruation, 2 mg of Estradiol Valerate tablets are given three times a day for 9 days, and if there is an endometrium with a thickness of more than 7 mm, 100 mg of progesterone ampoule daily until 12 weeks of pregnancy is prescribed. Intervention group:In the second group; To transfer the frozen fetus on the second day of menstruation, 2 mg Estradiol Valerate tablets are given three times a day for 9 days, and if there is an endometrium with a thickness of more than 7 mm, a Cyclogest suppository 400 mg twice a day for up to 12 weeks of Pregnancy is prescribed. Intervention group:In the third group; To transfer the frozen fetus on the second day of menstruation, 2 mg Estradiol Valerate tablets are given three times a day for 9 days. If there is an endometrium with a thickness of more than 7 mm, Prolotex 25 mg daily, subcutaneously for up to 12 weeks of Pregnancy is prescribed. Clinical Pregnancy. Timepoint: Ten weeks after starting treatment. Method of measurement: Blood tests and ultrasound. Abortion. Timepoint: 10 weeks after embryo transfer. Method of measurement: Blood tests and ultrasound. Ectopic Pregnancy. Timepoint: 5 weeks after embryo transfer. Method of measurement: Blood tests and ultrasound. Tehran University of Medical Sciences Approved 2019-03-10 Vice -Chancellar in Research Affairs -Tehran University of Medical Sciences Vice Chancellor for Research and Technology, sixth floor, Central University Organization, corner of Quds Street, Keshavarz Boulevard. Tehran Tehran Iran (Islamic Republic of)