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IRCT20171230038142N11 IRCT 2020-02-19 Esfahan University of Medical Sciences Comparing nebulized colistin with nebulized Tobramycin- Fosfomycin as an adjunctive treatment of ventilator associated pneumonia due to multi drug resistant acinetobacter Comparing nebulized colistin with nebulized Tobramycin- Fosfomycin as an adjunctive treatment of ventilator associated pneumonia due to multi drug resistant acinetobacter 2019-08-23 anticipated 60 Complete https://irct.ir/trial/45788 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients are first conveniently and easily selected from the list of patients with ventilator pneumonia admitted to the ICU center of Alzahra Hospital in Isfahan and then divided into two groups of 30 each using double blocks, Blinding description: Patients admitted to the ICU are not aware of the therapeutic content and the data analyzer has no information about the name and other characteristics of the patients. 2-3 ventilator associated pneumonia due to multi drug resistant acinetobacter. Intervention 1: Intervention group: The inhaled tobramycin + phosphomycin treatment group (treated with intravenous meropenem and clistine) included 30 patients with ventilator-associated pneumonia, whose response to cultures of severely resistant acinetobacter baumannii was noted, among patients admitted to the intensive care unit of Alzahra Hospital. Phosphomycin solution with 4% concentration (2 ml of this solution, 80 mg proportion) is introduced into the nebulizer jet chamber for patient use. This is accomplished by filtration using 100 nm filters at the appropriate pH (about 7) and with the appropriate tonicity of body fluids that do not cause irritation when inhaled. The Clinical Pulmonary Infection Score (CPIS) criterion is used to diagnose ventilator pneumonia. The criterion consists of 5 sections, each with a score of 0 to 2, and patients score between 0 and 10. Intervention 2: Intervention group: Intervention group: Inhaled clistine treatment group (treated with meropenem and intravenous clistine), including 30 patients with ventilator pneumonia, whose response to cultures of highly resistant acinetobacter baumannii was noted, was selected from patients in the intensive care units of Al-Zahra Hospital. Ventilator pneumonia diagnosis is used by the Clinical Pulmonary Infection Score (CPIS). The criterion consists of 5 sections each with a score of 0 to 2, and patients score between 0 and 10. Yes - There is a plan to make this available What will be shared: The information is shared two years after the results are published. When: The information is shared two years after the results are published. To whom: Doctors and Infectious Diseases Conditions: Compare information available with other medications or other therapies Where to obtain: Email a.hakamifard@med.mui.ac.ir and obtain permission from Isfahan University of Medical Sciences How to obtain: Email a.hakamifard@med.mui.ac.ir and obtain permission from Isfahan University of Medical Sciences Comments:
public Atusa Hakami Fafd
Al-Zahra Hospital, Sofah Boulevard.
Esfahan Iran (Islamic Republic of) 81746-73461 +98 31 3668 0048 a.hakamifard@med.mui.ac.ir Esfahan University of Medical Sciences scientific Atusa Hakami Fafd
Al-Zahra Hospital, Sofah Boulevard.
Esfahan Iran (Islamic Republic of) 81746-73461 +98 31 3668 0048 a.hakamifard@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Patient hospitalization in ICU Ages between 20 and 65 Diagnosis of ventilator pneumonia for the patient Diagnosis of cholesterol-sensitive Acinetobacter baumannii Patient satisfaction 20 years 60 years Both Diagnosis Another concomitant disease Start treatment of acinetobacter The patient died before the response J95.851 Ventilator associated pneumonia Treatment - Drugs Treatment - Drugs Intervention group: The inhaled tobramycin + phosphomycin treatment group (treated with intravenous meropenem and clistine) included 30 patients with ventilator-associated pneumonia, whose response to cultures of severely resistant acinetobacter baumannii was noted, among patients admitted to the intensive care unit of Alzahra Hospital. Phosphomycin solution with 4% concentration (2 ml of this solution, 80 mg proportion) is introduced into the nebulizer jet chamber for patient use. This is accomplished by filtration using 100 nm filters at the appropriate pH (about 7) and with the appropriate tonicity of body fluids that do not cause irritation when inhaled. The Clinical Pulmonary Infection Score (CPIS) criterion is used to diagnose ventilator pneumonia. The criterion consists of 5 sections, each with a score of 0 to 2, and patients score between 0 and 10. Intervention group: Intervention group: Inhaled clistine treatment group (treated with meropenem and intravenous clistine), including 30 patients with ventilator pneumonia, whose response to cultures of highly resistant acinetobacter baumannii was noted, was selected from patients in the intensive care units of Al-Zahra Hospital. Ventilator pneumonia diagnosis is used by the Clinical Pulmonary Infection Score (CPIS). The criterion consists of 5 sections each with a score of 0 to 2, and patients score between 0 and 10. Mortality rates. Timepoint: After completing the study. Method of measurement: Counting the number of patients. Duration of response to treatment. Timepoint: After completing the study. Method of measurement: Counting the number of days admitted and the number of patients saved. CPIS index. Timepoint: Before and after treatment. Method of measurement: questionnaire. Esfahan University of Medical Sciences Approved 2019-06-02 Ethics Committee of Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Hezar Jarib Ave. Isfahan Isfehan Iran (Islamic Republic of)