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IRCT20200117046164N1 IRCT 2020-04-18 Mashhad University of Medical Sciences Effect of the Probioti in treatment of Atopic Dermatitis. AD:Atopic Dermatitis The Effect of Probiotic cream containing bacteria killed in children with Atopic Dermatitis. 2020-05-20 anticipated 60 Complete https://irct.ir/trial/45790 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: A simple randomization will be carried out on an individual basis by Rand List software.The allocation will be seated by an independent monitor and will not be broken until the end of the study, Blinding description: The investigator assessing outcome and analyzing the data will be blinded to treatment allocation until the end of the study. 3 Atopic Dermatitis. Intervention 1: Control group: Topical Placebu ointment.in the intervention group,30 childs with Atopic Dermatitis will be treated with Placebu ointment every 12 hours for 4 weeks. Intervention 2: Intervention group: Obtaining topical ointment containing probiotics. In the intervention group, 30 children with atopic dermatitis will receive probiotic ointment lactobacillus palntarum every 12 hours for 4 weeks. In order to prepare probiotic cream from microbial bacterial culture, microbial suspension with 108 CFU / mL concentration It is prepared and incubated in MRS culture medium for 48 hours at 37. C. This product under the AllVia® brand contains 5% by weight of probiotics in cream base. To prepare the cream, after bacterial inactivation, the bacterial precipitate is weighed and mixed with a certain amount of the cream and mixed until a cream containing 5% probiotic is finally obtained. Yes - There is a plan to make this available What will be shared: All data will be shared after being unidentified. When: All any time To whom: It will be free for every one. Conditions: There are no special conditions. Where to obtain: Email: moazzenn@mums.ac.ir, 09151034644, Dr Nasrin Moazzen, Akbar Hospital - Kaveh sreet - Mashhad. How to obtain: The request will be checked, then data will be sent by Email in 1 month. Comments:
public Dr Nasrin Moazzen
Fakouri Blvd, Akbar children Hospital, Mashhad
Mashhad Iran (Islamic Republic of) 9195933516 +98 51 3713 3101 moazzenn@mums.ac.ir Mashhad University of Medical Sciences scientific Nasrin Moazzen
Fakouri Blvd, Akbar children Hospital, Mashhad
Mashhad Iran (Islamic Republic of) 9195933516 +98 51 3713 3101 moazzenn@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Children with moderate to severe Disease. 6 months 5 years Both Children who have other skin conditions at the same time. Children whose parents declare their full written informed consent to participate in this study. Treatment - Drugs Treatment - Drugs Control group: Topical Placebu ointment.in the intervention group,30 childs with Atopic Dermatitis will be treated with Placebu ointment every 12 hours for 4 weeks. Intervention group: Obtaining topical ointment containing probiotics. In the intervention group, 30 children with atopic dermatitis will receive probiotic ointment lactobacillus palntarum every 12 hours for 4 weeks. In order to prepare probiotic cream from microbial bacterial culture, microbial suspension with 108 CFU / mL concentration It is prepared and incubated in MRS culture medium for 48 hours at 37. C. This product under the AllVia® brand contains 5% by weight of probiotics in cream base. To prepare the cream, after bacterial inactivation, the bacterial precipitate is weighed and mixed with a certain amount of the cream and mixed until a cream containing 5% probiotic is finally obtained. Atopic Dermatitis severity index. Timepoint: Weeks 0, 2, 4. Method of measurement: Observation. Mashhad University of Medical Sciences Approved 2019-07-23 Ethics committee of mashhad University of Medical Sciences Akbar Hospital Mashhad Razavi Khorasan Iran (Islamic Republic of)