]>
IRCT20151107024909N9 IRCT 2020-03-11 Iran University of Medical Sciences Comparison of muscle relaxant dose of cis-atracurium based on body fat mass (FFM), total body weight (TBW) and ideal body weight (IBW) in patients undergoing obesity surgery. Comparison of muscle relaxant dose of cis-atracurium based on body fat mass (FFM), total body weight (TBW) and ideal body weight (IBW) in patients undergoing obesity surgery. 2020-01-29 anticipated 60 Complete https://irct.ir/trial/45892 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization is done using identical envelopes, each envelope containing the name of one of the groups under study. These envelopes are available to patients who are candidates for bariatric surgery. They fall into one of three study groups (FFM - TBW - IBW) based on their envelope. According to the inclusion and exclusion criteria, 60 patients were finally selected for the study, Blinding description: Patients are divided into study groups using the same prepared envelopes and none of the patients are aware of the assigned group. 3 Obesity. Intervention 1: Intervention group1:In the first group, the dose of cis atracurium was injected based on body fat mass (FFM) and changed during the dose of the drug based on the patient's hemodynamic status. It is categorized as non-dollarized. It is used in the anesthesia process for intubation and relaxation of skeletal muscle to facilitate surgery as well as mechanical ventilation of the patient. Cis atracurium is categorized by time of action except for moderate to effective medications. Ampoule concentration is 2 mg / ml, 2.5 ml and manufactured by the Daruyab company. Intervention 2: Intervention group2: In the second group, the dose of cisatracurium is injected based on total body weight (TBW) and changes in the dose of the drug are based on the patient's hemodynamic status during surgery.It is categorized as non-dollarized. It is used in the anesthesia process for intubation and relaxation of skeletal muscle to facilitate surgery as well as mechanical ventilation of the patient. Cis atracurium is categorized by time of action except for moderate to effective medications. Ampoule concentration is 2 mg / ml, 2.5 ml and manufactured by the Daruyab company. Intervention 3: Intervention group: In the third group, the dose of cisatracurium is injected based on ideal body weight (IBW) and changes in the dose of the drug are based on the patient's hemodynamic status during surgery.It is categorized as non-dollarized. It is used in the anesthesia process for intubation and relaxation of skeletal muscle to facilitate surgery as well as mechanical ventilation of the patient. Cis atracurium is categorized by time of action except for moderate to effective medications. Ampoule concentration is 2 mg / ml, 2.5 ml and manufactured by the Daruyab company. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Faranak Rokhtabnak
No. 14 , Dejamjo Ave., Kamranieh Town
Tehran Iran (Islamic Republic of) 553406080050 +98 21 8871 7272 rolhtabnak.f@iums.ac.ir Iran University of Medical Sciences scientific Faranak Rokhtabnak
No. 14 , Dejamjo Ave., Kamranieh Town
Tehran Iran (Islamic Republic of) 553406080050 +98 21 8871 7272 rolhtabnak.f@iums.ac.ir Iran University of Medical Sciences Iran (Islamic Republic of) Ages 18 to 60 Patients with physical level below 3 according to the American Society of Anesthesiologists classification BMI greater than ²35 kg / m Normal kidney and liver function confirmed by routine screening tests 18 years 60 years Both Pregnancy , Neuromuscular Disease Treatment with Well-known Interventions in Muscle Neurotransmission Psychological Disorder Allergy to Cis-atracurium Criteria for Difficult Intubation E66 Overweight and obesity Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group1:In the first group, the dose of cis atracurium was injected based on body fat mass (FFM) and changed during the dose of the drug based on the patient's hemodynamic status. It is categorized as non-dollarized. It is used in the anesthesia process for intubation and relaxation of skeletal muscle to facilitate surgery as well as mechanical ventilation of the patient. Cis atracurium is categorized by time of action except for moderate to effective medications. Ampoule concentration is 2 mg / ml, 2.5 ml and manufactured by the Daruyab company. Intervention group2: In the second group, the dose of cisatracurium is injected based on total body weight (TBW) and changes in the dose of the drug are based on the patient's hemodynamic status during surgery.It is categorized as non-dollarized. It is used in the anesthesia process for intubation and relaxation of skeletal muscle to facilitate surgery as well as mechanical ventilation of the patient. Cis atracurium is categorized by time of action except for moderate to effective medications. Ampoule concentration is 2 mg / ml, 2.5 ml and manufactured by the Daruyab company. Intervention group: In the third group, the dose of cisatracurium is injected based on ideal body weight (IBW) and changes in the dose of the drug are based on the patient's hemodynamic status during surgery.It is categorized as non-dollarized. It is used in the anesthesia process for intubation and relaxation of skeletal muscle to facilitate surgery as well as mechanical ventilation of the patient. Cis atracurium is categorized by time of action except for moderate to effective medications. Ampoule concentration is 2 mg / ml, 2.5 ml and manufactured by the Daruyab company. Duration of muscle relaxation. Timepoint: During surgery. Method of measurement: Minutes. Dose of Cisatracurium. Timepoint: During surgery. Method of measurement: Mg, syringe. Need for antagonism. Timepoint: During surgery and after surgery. Method of measurement: Mg, syringe. Iran University of Medical Sciences Approved 2020-01-21 Ethics committee of Iran University of Medical Sciences No. 14 , Dejamjo Ave., Kamranieh Town Tehran Tehran Iran (Islamic Republic of)