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IRCT20200209046433N1 IRCT 2020-03-11 Esfahan University of Medical Sciences Evaluation of the efficacy of a new Apnea test method in confirmation of brain death and comparison with the current method Evaluation of the efficacy of a new Apnea test method in confirmation of brain death and comparison with the current method 2020-02-04 anticipated 60 Complete https://irct.ir/trial/45993 interventional Randomization: Not randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Diagnostic. N/A Brain Death. Intervention 1: Intervention group: The intensive care unit of Al-Zahra teaching hospital 100% oxygen was given to the patient for 10 minutes before the patient was removed from the ventilator. The patient is then removed from the apparatus and oxygenated at 6 liters per minute by a narrow Nellon catheter inserted into the endotracheal tube. Serial arterial blood gas testing allows the blood carbon dioxide to gradually reach 60 mm Hg, or rise to as much as 20 mm Hg. If you do not see any respiratory activity, the apnea test confirms brain death. In the new method, induction hypercapnia is used instead of hyperventilating and then separating the brain death patient from the ventilator, and with a minimum volume of minutes adjustable on the ventilator, increased blood carbon dioxide and instead of repeated arterial blood gas measurements, Expired carbon dioxide calculates blood carbon dioxide levels, and when exhaled carbon dioxide reaches the target, it examines arterial blood gases and compares exhaled carbon dioxide with blood carbon dioxide. Intervention 2: Control group: In this group, only the classic apnea test is performed. Yes - There is a plan to make this available What will be shared: Information can be shared two years after release. When: Information can be shared two years after release. To whom: Doctors and nurses Conditions: Compare this method with another method Where to obtain: Send kashefi@med.mui.ac.ir an email How to obtain: Send kashefi@med.mui.ac.ir an email Comments:
public Parviz Kashefi
N6,vatan lane,mir st Isfahan
Isfahan Iran (Islamic Republic of) 81746-73461 +98 31 3662 2596 Kashefi@med.mui.ac.ir Esfahan University of Medical Sciences scientific Parviz Kashefi
N6,vatan lane,mir st Isfahan
Isfahan Iran (Islamic Republic of) 81746-73461 +98 31 3662 2596 Kashefi@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Sick of brain death. Get written consent from the patient's legal relatives 12 years no limit Both Lack of parental consent to do Apnea test Cases that are not hemodynamically stable. G93.82 Brain death Early detection Diagnosis Intervention group: The intensive care unit of Al-Zahra teaching hospital 100% oxygen was given to the patient for 10 minutes before the patient was removed from the ventilator. The patient is then removed from the apparatus and oxygenated at 6 liters per minute by a narrow Nellon catheter inserted into the endotracheal tube. Serial arterial blood gas testing allows the blood carbon dioxide to gradually reach 60 mm Hg, or rise to as much as 20 mm Hg. If you do not see any respiratory activity, the apnea test confirms brain death. In the new method, induction hypercapnia is used instead of hyperventilating and then separating the brain death patient from the ventilator, and with a minimum volume of minutes adjustable on the ventilator, increased blood carbon dioxide and instead of repeated arterial blood gas measurements, Expired carbon dioxide calculates blood carbon dioxide levels, and when exhaled carbon dioxide reaches the target, it examines arterial blood gases and compares exhaled carbon dioxide with blood carbon dioxide. Control group: In this group, only the classic apnea test is performed. Cost of performing repeated arterial blood gas tests. Timepoint: During hospitalization. Method of measurement: Induction of Hypercapnia. Hypoxia. Timepoint: During hospitalization. Method of measurement: Pulse Oximeter. Hypotension. Timepoint: During hospitalization. Method of measurement: Mercury barometer. Bradycardia and Tachycardia. Timepoint: During hospitalization. Method of measurement: Electrocardiogram. Pneumothorax. Timepoint: During hospitalization. Method of measurement: Examination. Esfahan University of Medical Sciences Approved 2020-02-01 Ethics committee of Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Hezar Jerib Ave. Isfahan Isfehan Iran (Islamic Republic of)