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IRCT20180513039637N3 IRCT 2020-05-24 Islamic Azad University Effect of Curcumin supplementation on muscle damage Effects of curcumin supplementation in comparison with placebo on serum creatinine kinase (CK), lactate dehydrogenase (LDH), malonyl dialdehyde (MDA), total antioxidant capacity (TAC), and interleukin-6 (IL-6) after taekwondo race in taekwondo men 2018-05-01 anticipated 19 Complete https://irct.ir/trial/46178 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Other, Purpose: Education/Guidance, Randomization description: Using simple randomization, individuals were divided into two homogeneous groups (curcumin and placebo). Randomization tools were also sealed envelopes. The randomization unit was also individual. The odd numbers in the envelope showed the subjects in the curcumin group, and the even numbers showed the subjects in the placebo group. The allocation concealment was such that none of the subjects knew the meaning of the numbers in the envelope and did not know which group they belonged to, Blinding description: The capsules were identical in weight (1 g, 0.5 g), form, color and packing. They were coded and No subjects were aware of the contents of the capsules until the end of the study. N/A Dose not apply. Intervention 1: Intervention group: 9 male Taekwondoers who took curcumin supplements (4 g/d) for 5 days. 3 days after eating curcumin, subjects participated in Taekwondo competition (3 races with 30 min rest) and received curcumin for up to two days after the competition. In this study, the curcumin supplement produced by Karma Company, Iran was used. Intervention 2: Control group: 9 male Taekwondoers who took placebo supplements (4 g/d of rice flour) for 5 days. 3 days after eating placebo, subjects participated in Taekwondo competition (3 races with 30 min rest) and received placebo for up to two days after the competition. Yes - There is a plan to make this available What will be shared: In adress: Sportdezh.rzb.ir When: Every time To whom: everyone Conditions: Modeling of the subject, supplementation method and training method is allowed Where to obtain: Send an email to hadipourmanaf@yahoo.com or visit Sportdezh.rzb.ir. How to obtain: Send an email to hadipourmanaf@yahoo.com or visit Sportdezh.rzb.ir. Comments:
public Hadi Pourmanaf
No. 497, Banafsheh alley, Valliamr boulevard
Tabriz Iran (Islamic Republic of) 00000-00000 +98 41 3667 3861 hadi.pvrmnaf@ut.ac.ir Tabriz University of Medical Sciences scientific Leila Nikniaz
No. Azadi Alvd., Tabriz Town
Tabriz Iran (Islamic Republic of) 00000-00000 +98 41 3667 3861 Nikniazleila@gmail.com Tabriz University of Medical Sciences Iran (Islamic Republic of) At least 3 years of experience in taekwondo competitions Athletes' maximum oxygen consumption (VO2 max) should be more than 45 percent 19 years 27 years Male Having a history of diabetes Having a history of cardiovascular disease Having a history of respiratory disease Having food allergies Having a drug allergy Use of inflammatory agents before or during the study Use a sports supplement before or during the study Use the drug before or during the study Other Placebo Intervention group: 9 male Taekwondoers who took curcumin supplements (4 g/d) for 5 days. 3 days after eating curcumin, subjects participated in Taekwondo competition (3 races with 30 min rest) and received curcumin for up to two days after the competition. In this study, the curcumin supplement produced by Karma Company, Iran was used. Control group: 9 male Taekwondoers who took placebo supplements (4 g/d of rice flour) for 5 days. 3 days after eating placebo, subjects participated in Taekwondo competition (3 races with 30 min rest) and received placebo for up to two days after the competition. Serum creatine kinase (CK) level in taekwondo athletes. Timepoint: Blood sampling was performed before the start of supplementation (3 day before the race), one hour before the race, immediately after the race, 24 hours and 48 hours after the race (5 stages). Method of measurement: Creatine kinase kit. Serum lactate dehydrogenase (LDH) level in taekwondo athletes. Timepoint: Blood sampling was performed before the start of supplementation (3 day before the race), one hour before the race, immediately after the race, 24 hours and 48 hours after the race (5 stages). Method of measurement: lactate dehydrogenase kit. Serum Malonyl Dialdehyde (MDA) Levels in Taekwondo Athletes. Timepoint: Blood sampling was performed before the start of supplementation (3 day before the race), one hour before the race, immediately after the race, 24 hours and 48 hours after the race (5 stages). Method of measurement: Malonyl Dialdehyde kit. Serum total antioxidant capacity (TAC) levels in Taekwondo athletes. Timepoint: Blood sampling was performed before the start of supplementation (3 day before the race), one hour before the race, immediately after the race, 24 hours and 48 hours after the race (5 stages). Method of measurement: total antioxidant capacity kit. Serum Interleukin-6 (IL-6) Level in Taekwondo Athletes. Timepoint: Blood sampling was performed before the start of supplementation (3 day before the race), one hour before the race, immediately after the race, 24 hours and 48 hours after the race (5 stages). Method of measurement: Interleukin-6 kit. Islamic Azad University Approved 2020-04-12 Ethics committee of Sport Science Research Institute No.3, 5th closed alley, Miremad street., Qods Town Tehran Tehran Iran (Islamic Republic of)