IRCT20171128037666N2 IRCT 2020-04-05 Bagheiat-allah University of Medical Sciences Comparison of stress system in patients with multiple sclerosis before and after TSST intervention Comparison of the stress response system before and after the trait social stress test (TSST) in multiple sclerosis patients 2020-05-12 anticipated 25 Complete https://irct.ir/trial/46226 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Basic scienece. N/A Multiple sclerosis. the social stress test (TSST) use to induce stress. The period of induced stress lasts approximately 10 minutes and is divided into 5-minute components. Participants will talk about their job during the first 5 minutes of the test. The judges have been trained to maintain neutral expressions throughout the test. The presentation is immediately followed by the mental arithmetic component, during which the participant is asked to count backward from 1,022 in steps of 13. If a mistake is made, then they must start again from the beginning. This component lasts for 5 minutes and is followed by a recovery period. We will measure salivary cortisol and heart rate by ECG.. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no more data.