IRCT20200226046624N1 IRCT 2020-03-07 Tehran University of Medical Sciences Efficacy of dimethyl fumarate administration vs placebo on neurosurgical brain induced injury measured by S100 beta protein concentration and performance (Karnofsky scale) among glioblastoma multiform patient Comparison the efficacy of dimethyl fumarate administration vs placebo on neurosurgical brain induced injury measured by S100 beta protein concentration and performance (Karnofsky scale), in glioblastoma multiform patient operated in Shariati Hospital from 2018 to 2021 2018-03-21 anticipated 72 Complete https://irct.ir/trial/46358 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The random listing of patients in groups is based on random blocks of 4, 6, and 8 and is centrally performed by the concealment officer and the person performing the randomization of each related group that unaware of intervention, Blinding description: Patients in both groups receive routine drug therapy, and the patient will be prescribed medications as before. Routine drug therapy includes phenytoin, dexamethasone, and cefazolin. Patients treated with dimethyl fumarate will receive three pills (240 mg/day) daily from one week before surgery in addition to routine treatments. The control group will go through the same procedure as the treatment group, with the exception of taking three dimethyl fumarate tablets per day that will not be prescribed in this group, and placebo tablets of the same form and other non-mainstream drugs (e.g., preservatives) will be received. The surgeon, patient, and statistical analyst will be blind to this procedure. 3 Gliobalstom multiforme. Intervention 1: Intervention group: Routine treatment (including phenytoin, dexamethasone and cefazolin) plus three dimethyl fumarate tablets (240 mg daily) one week before surgery. Intervention 2: Control group: Routine treatment (including phenytoin, dexamethasone and cefazolin) plus three placebo tablets and non-mainstream drugs (such as the same preservatives) will be received one week before surgery. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information