IRCT20100524004010N28 IRCT 2020-04-11 Shahid Beheshti University of Medical Sciences The effect of glutamine on clinical outcomes, quality of life and intestinal permeability in patients with irritable bowel syndrome The effect of low FODMAP (Fermentable, Oligo-, Di-, Mono-saccharides and Polyols) diet with glutamine supplement versus placebo on clinical outcomes, quality of life and intestinal permeability in patients with irritable bowel syndrome 2020-06-20 anticipated 50 Complete https://irct.ir/trial/46426 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: The method used in this study to create a randomization process is simple randomization, so we utilize random number table. Beginning of the study, each person is randomly assigned to one of the 2 study groups according to the randomized distribution table, Blinding description: In this study, patients will receive a supplement or placebo with a low fodmap diet for 6 weeks depending on the group they are in. Patients in the supplement group will receive L-glutamine powder, and the placebo group will receive the iso whey protein powder which is similar in shape and color to the supplement. 5 g three times daily in 230 ml of water. Before starting the study, powdered cans are coded by a person other than the researcher into group A and group B to the purpose of not informing the researcher of the type of powder used by each group. N/A irritable bowel syndrome. Intervention 1: Intervention group: will receive15 g (5 grams three times a day) L- glutamine supplement plus low FODMAP diet for 6 weeks. Intervention 2: Control group: will receive 15 g (5 grams three times a day) iso whey supplement plus low FODMAP diet for 6 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is there is no more information