IRCT20161017030336N7 IRCT 2020-03-30 Arak University of Medical Sciences Comparison of Botox and Nitroglycerin Ointment on Anal Fissure Repair Comparison of Botox and Nitroglycerin Ointment on Anal Fissure Repair 2020-03-02 anticipated 38 Complete https://irct.ir/trial/46430 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment. 2-3 Condition 1: Chronic Anal fissure. Condition 2: Acute anal fissure. Condition 3: Anal fissure, unspecified. Condition 4: Abscess of anal and rectal regions. Intervention 1: Intervention group (A) will use 0.2% Nitroglycerin or Glycerin Trinitrate ointment made by Caspian Tamin Pharmaceutical Company at the wound site, twice daily for 12 hours for 6 weeks. During this 6-week period, patients will use 3 tubes of ointment. Patients are followed up in the first week, second week, fourth week and sixth month after treatment. Nitroglycerin ointment helps to cure fissile disease by lowering sphincter muscle pressure and increasing blood flow. The most important complication after using this ointment is headache and hypotension. Intervention 2: Intervention group (B) will use Botox ointment at the wound site, twice daily for 12 hours for 6 weeks. During this 6-week period, patients will use three ointment tubes. Follow-up is done in the first week, second week, fourth week and six months after treatment.Botox ointment can help treat this condition. In some cases, it can be injected to relieve pain when using other therapies. This procedure is performed using botulinum toxin to the wound. This toxin causes paralysis of the sphincter muscle for a limited time. This can relieve muscle cramps, or spasm, and relieve the pain of the patient. In addition, this toxin can also help repair the fissure caused by fissures. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information