IRCT201008084365N4 IRCT 2011-01-21 Mazandaran University of Medical Sciences Evaluation of metformin induced lactic acidosis in Type 2 Diabetic Patients after CABG Surgery Evaluation of metformin induced lactic acidosis in Type 2 Diabetic Patients after CABG Surgery 2010-09-23 anticipated 200 Complete https://irct.ir/trial/4653 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment. N/A Type 2 diabetes. Intervention 1: Control group: regular insulin infusion according to the center protocol, as well as two placebo tablet every 12 hours. Intervention 2: Intervention group: regular insulin infusion according to the center protocol, as well as two 500 mg metformin tablets every 12 hours.

public Hadi Darvishi Khezri

Mazandaran University of Medical Sciences, Moallem Square

Sari Iran (Islamic Republic of) 48175-866 +98 15132612458 hadidarvishi87@yahoo.com Mazandaran University Of Medical Sciences scientific Afshin Gholipour Baradari MD

Mazandaran University of Medical Sciences, Moallem Square

Sari Iran (Islamic Republic of) 48175-866 +98 15132612458 gholipourafshin@mazums.ac.irgholipourafshin@yahoo.com Mazandaran University Of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Informed written consent, Elective CABG surgery, Type 2 diabetes, Age between 35 and 75 years, Use of the cardiopulmonary pump during surgery, Hemodynamic stability (MAP> 60, absence of dangerous dysrhythmia or heart rate between 50-11) Exclusion criteria: Liver dysfunction (SGPT and SGOT greater than 75), Renal dysfunction (serum creatinine greater than 1.5 in two consecutive tests), Heart failure (ejection fraction less than 30 percent), Serum lactate greater than 5mmo /l or increased more than 2mmol /l, Serum PH less than 7.25 or BE less than 6 mmol /l, Arterial oxygen partial pressure less than 60 mm Hg in two consecutive ABG, Use of contrast or angiography during two days before surgery, Potassium less than 3 meq/L, Nausea and vomiting, Use of metformin metabolism Inhibitor drugs such as amiodarone and cimetidine, Use of high dose inotropes more than three hours after extubation, Prolonged intubation (more than 6 hours after surgery), Need for reoperation for any reason 35 years 75 years Both E11.7 Non-insulin dependent diabetes mellitus Placebo Treatment - Drugs Control group: regular insulin infusion according to the center protocol, as well as two placebo tablet every 12 hours Intervention group: regular insulin infusion according to the center protocol, as well as two 500 mg metformin tablets every 12 hours Lactate. Timepoint: every 2 hours. Method of measurement: mg/dl , Laboratory kit. Blood suger. Timepoint: every 2 hours. Method of measurement: mg/dl , Laboratory kit. PH. Timepoint: every 2 hours. Method of measurement: Laboratory kit. Base exess. Timepoint: every 2 hours. Method of measurement: mmol/l, Laboratory kit. Creatinine. Timepoint: every 6 hours. Method of measurement: mg/dl , Laboratory kit. Potassium serum level. Timepoint: Every 6 hours. Method of measurement: laboratory test. Mazandaran University of Medical Sciences Approved 2011-01-05 Mazandaran University of Medical Sciences Moallem Square Sari Iran (Islamic Republic of)