IRCT20090801002266N14 IRCT 2020-06-02 Esfahan University of Medical Sciences Effect of oral ketamine at doses of 1 and 2 mg/kg on depression treatment Comparison Between the Effect of 1 & 2 mg/kg per oral Ketamine on Control and Relapse of Depressive Symptoms in Treatment-Resistant Depressed people: A Randomized, Double-Blind Clinical Trial 2020-06-21 anticipated 60 Complete https://irct.ir/trial/46543 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: 60 patients selected to participate in the study were randomly assigned to one of two intervention groups. In this way, each patient chooses one of the sealed envelopes in which one of the two intervention methods is randomly placed by computer software, Blinding description: To apply the terms of a double-blind study, 1 and 2 mg/kg doses of ketamine as a solution in a glass of juice will be prepared by the nurse (without the knowledge of the researcher), then will be marked with A and B labels, and provided to the researcher to give to the patients. 2-3 Treatment-Resistant Major Depressive Disorder. Intervention 1: Intervention group: For patients in the first group, 2 mg/kg of ketamine as a solution in a glass of fruit juice orally 2 times a week (for 6 weeks) will be prescribed. Intervention 2: Intervention group: For patients in the second group, 1 mg/kg of ketamine as a solution in a glass of fruit juice orally 2 times a week (for 6 weeks) will be prescribed. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information