IRCT20200317046801N1 IRCT 2020-03-27 Tehran University of Medical Sciences The effect of vitamin B6 in bipolar patients Evaluation of the effect of vitamin B6 as adjunctive therapy in ameliorating symptoms of acute mania in patients with bipolar disorder Type 1 hospitalized in Roozbeh Hospital; a double-blind placebo-controlled clinical trial 2019-11-01 anticipated 50 Complete https://irct.ir/trial/46585 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization is simple and individual, is a random tool of random numbers and how to construct a random sequence. In order to prevent selection bias, the researchers employ a randomization method as well as hiding random allocation to report it correctly. These researchers can gain valid results by better understanding this method and its proper implementation, Blinding description: Participants, lead investigator, healthcare personnel (physicians, nurses, physiotherapists, etc.) responsible for patient care, data collection and outcome assessors, and the Data Safety and Monitoring Committee Those who draft the article are not aware of any type of prescription drug. 3 BIPOLAR DISORDER. Intervention 1: Fifty Patients with type 1 bipolar disorder in the mania phase are randomly divided into two groups. 25patients in the intervention group receive standard lithium carbonate and vitamin B 6medication treatment, and they will be evaluated for improvement of mania symptoms, cognitive symptoms, and brain map within 8 weeks. Intervention 2: 25 patients in the control group receive standard lithium carbonate and placebo treatment and are treated for 8 weeks for improvement in manic and cognitive symptoms and brain map. No - There is not a plan to make this available Justification or reason for not sharing IPD is After the article is published, all the results will be made available to those interested