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IRCT20190810044500N2 IRCT 2020-04-01 Yazd University of Medical Sciences Evaluation of effects of oral medroxyprogesterone and donepezil in improvement of respiratory status and facilitation in weaning of mechanical ventilation in patients undergoing mechanical ventilation in ICUs Evaluation of effects of oral medroxyprogesterone and donepezil in improvement of respiratory status and facilitation in weaning of mechanical ventilation in patients undergoing mechanical ventilation in ICUs of Shahid Dr. Rahnemoon Yazd 2019-12-21 anticipated 45 Complete https://irct.ir/trial/46766 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: The three drugs Donepezil and Medroxyprogesterone and placebo were named in letters A, B and C. The order of prescribing of medications to the specimens was determined using a random number table, Blinding description: Blindness was performed on clinical caregivers, including physicians and nurses, as well as variables assessors and data analysts. 2 weaning of mechanical ventilation. Intervention 1: Intervention group:. Intervention 2: Control group:. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Fatemeh Saghafi
Professor Hesabi Blvd., Yazd Province, Yazd, Iran
Yazd Iran (Islamic Republic of) ۸۹۱۵۱۷۳۱۴۹ +98 35 3820 3419 F.saghafi@ssu.ac.ir Yazd University of Medical Sciences scientific Fatemeh Saghafi
Professor Hesabi Blvd., Yazd Province, Yazd, Iran
Yazd Iran (Islamic Republic of) ۸۹۱۵۱۷۳۱۴۹ +98 35 3820 3419 F.saghafi@ssu.ac.ir Yazd University of Medical Sciences Iran (Islamic Republic of) Mechanical ventilation through endotracheal tube for at least 24 hours oxygen saturation greater than 90% FIO2 less than 50% PEEP less than 8 cm water hemodynamic stability over the past 12 hours sedation withdrawal or sedation reduction Over the past 48 hours neurological status stabilized with Ramsay's score less than 5 temperature between 36 and 39 degrees 18 years no limit Both Pregnancy or lactation under 18 years of age tracheostomy hepatic encephalopathy cerebral edema acute hydrocephalus myasthenia gravis Acute polyneuropathy lack of decision to discontinue respiratory support prolonged cardiac arrest with poor neurologic prognosis coincident extubation with day one acute right ventricular failure renal failure plasma urea exceeding (25 mol / L), Plasma creatinine greater than (180 mol / min) or creatinine clearance less than 30 ml / min, or more than 25% increase in creatinine over the past 24 hours contrast injection over the past six hours Serum sodium level greater than (150 m Eq) / L serum potassium level less than 3.5 (m Eq) / L metabolic alkalosis with arterial pH greater than 7.5 need for sedation or unconsciousness concurrent administration of drugs Potential respiratory stimulants such as doxapram and medroxyprogesterone hypothyroidism Known allergy to donepezil or medroxy progesterone Treatment - Drugs Placebo Intervention group: Control group: Blood gas includes PO2, PCO2, PHCO3, O2 saturation and PH. Timepoint: Before intervention and one day after and after weaning of mechanical ventilation. Method of measurement: blood sample. Hemoglobin. Timepoint: Before intervention and one day after and after weaning of mechanical ventilation. Method of measurement: blood sample. Level of consciousness. Timepoint: Before intervention and one day after and after weaning of mechanical ventilation. Method of measurement: glass coma scale. Sofa score. Timepoint: Before intervention and one day after and after weaning of mechanical ventilation. Method of measurement: Scoring based on pulmonary, coagulation, hepatic, cardiovascular, central nervous system and renal status. Duration of weaning. Timepoint: From the process of separation from the device to the patient's spontaneous breathing. Method of measurement: Counting the number of days. Yazd University of Medical Sciences Approved 2019-11-11 faculty of ethics of medical sciences - shahid sadoughi university of medical sciences Gomnam shohada boulevard - shahid sadoughi university of medical sciences Yazd Yazd Iran (Islamic Republic of)