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IRCT20190810044500N6 IRCT 2020-09-05 Yazd University of Medical Sciences Evaluating the effects of symbiotic therapy in male infertility with idiopathic oligoastenospermia Evaluating the effects of symbiotic therapy in male infertility with idiopathic oligoastenospermia 2020-09-22 anticipated 40 Complete https://irct.ir/trial/46773 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Patients are randomly divided into two groups of recipients of femoral lactate or placebo capsules using Random Allocation software using reciprocating blocks, Blinding description: All stages will be covered by the patient, physician, and evaluator. The first presenter identifies the sequence of assignment of patients according to the order of entry of the patients to the study and places the drugs in a uniform envelope and identifies them with A or B codes. He then identifies the medications that are appropriate for each individual according to the above description and puts them in special envelopes and delivers them to patients. 2 Idiopathic oligoasthenospermia. Intervention 1: Intervention group:They receive FamiLact capsules once a day for 4 weeks. Intervention 2: Control group: They receive placebo once a day for 4 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Fatemeh Saghafi
Professor Hesabi Blvd, Yazd Province, Yazd, Iran
Yazd Iran (Islamic Republic of) 8915173149 +98 35 3820 3419 F.saghafi@ssu.ac.ir Yazd University of Medical Sciences scientific Fatemeh Saghafi
Professor Hesabi Blvd, Yazd Province, Yazd, Iran
Yazd Iran (Islamic Republic of) 8915173149 +98 35 3820 3419 F.saghafi@ssu.ac.ir Yazd University of Medical Sciences Iran (Islamic Republic of) Age 20 to 50 years Sperm concentration below 15 million per cc Percentage of progressive motile spermatozoa < 32% Total ejaculated spermatozoa<39*106 Total motility <40% Normal serum levels of free testosterone, Prolactin, Luteinizing hormone, Follicle-stimulating hormone 20 years 50 years Male Drug or alcohol abuse Concentration of white blood cells in semen > 106 per cc Possibility of being treated with gonadotropins, anabolic steroids, cancer chemotherapy, NSAIDs, infertility medications in the last two months Previous history of chemotherapy or radiotherapy for cancer Existence of palpable varicocele X-ray history of the past eight months Y chromosome microdeletion Karyotype alterations Testicular atrophy and testicular failure Other secondary causes of infertility A history of liver problems and a history of allergy to clomiphene Percentage of typical forms<4% Ejaculated volume <1.5 ml Abnormal serum levels of free testosterone, Prolactin, Luteinizing hormone, Follicle-stimulating hormone Treatment - Drugs Placebo Intervention group:They receive FamiLact capsules once a day for 4 weeks. Control group: They receive placebo once a day for 4 weeks. Sperm concentration in semen. Timepoint: Before the intervention and after the intervention. Method of measurement: Spermatogram test. Sperm motility in semen. Timepoint: Before the intervention and after the intervention. Method of measurement: Spermatogram test. Sperm morphology in Semen. Timepoint: Before the intervention and after the intervention. Method of measurement: Spermatogram test. Semen fluid volume. Timepoint: Before the intervention and after the intervention. Method of measurement: Spermatogram test. Semen fluid Power Hydrogen. Timepoint: Before the intervention and after the intervention. Method of measurement: Spermatogram test. Serum concentration of free testosterone, prolactin, luteinizing hormone, follicle-stimulating hormone. Timepoint: Before the intervention and after the intervention. Method of measurement: Blood test. Age. Timepoint: Before the intervention and after the intervention. Method of measurement: Questionnaire. Height. Timepoint: Before the intervention and after the intervention. Method of measurement: Questionnaire. Weight. Timepoint: Before the intervention and after the intervention. Method of measurement: Questionnaire. Yazd University of Medical Sciences Approved 2020-07-07 Faculty of ethics of medical sciences, shahid sadoughi university of medical sciences Professor Hesabi Blvd, Yazd Province Yazd Yazd Iran (Islamic Republic of)