]>
IRCT20200404046933N1 IRCT 2020-04-12 Mashhad University of Medical Sciences Evaluation the effect of licorice for treatment of coronavirus LCS Evaluation the effect of aqueous extract of licorice on coronavirus outpatients: A randomized, double-blind, placebo-controlled clinical trial 2020-04-20 anticipated 40 Complete https://irct.ir/trial/46893 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Randomization in three stages: 1- Generation simple or limited randomization will be done based on a table of random numbers 2- Allocation concealment: which is done in the form of coded boxes (numbered drug containers) with a random sequence. In this method, a number of boxes with the same shape and size are numbered based on random sequences and contain drugs or placebo that have a completely similar appearance. 3- Execution of random allocation process: A: Identify the person who creates the random sequence B: A person who evaluates and registers researchers in terms of inclusion and exclusion criteria C: The person who assigned the participants to the groups: infectious diseases specialist The main researcher of the project, who creates a random sequence, does not interfere in other stages of randomization, including registration and allocation of participants, and the person involved in creating a random program is separate from other researchers, Blinding description: the medicine in the form of similar capsule but with the alphabetics A or B will be delivered to physician and patients. 2 Covid-19. Intervention 1: Intervention group: In addition to the standard treatment regimen for covid-19, capsules which have aqueous licorice extract containing 80 mg of the active ingredient glycyrrhizin will be given three times a day for 2 weeks. Licorice capsules are formulated at the Mashhad School of Pharmacy with the ineffective ingredients of Ovisil and Arozil. Intervention 2: Control group: ]n addition to general drugs for treatment of corona, the patients take placebo capsule 3 times a day for 14 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Undecided - It is not yet known if there will be a plan to make this availab
public Gholamreza Karimi
Vakil abad Blvd
Mashhad Iran (Islamic Republic of) 9177948954 +98 51 3180 1191 karimig@mums.ac.ir Mashhad University of Medical Sciences scientific Gholamreza Karimi
Vakil abad Blvd- pharmacy school
Mashhad Iran (Islamic Republic of) 177948954 +98 51 3180 1191 karimig@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) Patients diagnosed for coronavirus according to clinic such as fever, cough and mylagia Patients diagnosed for coronavirus according to paraclinic such as lymphopenia and increase of CRP Patients in the range of 18-65 years old 18 years 65 years Both Sensitivity to licorice and it derivatives Patients with hepato, renal or respiratory disorders Patients who take cytotoxic or corticosteroid drugs Nursing or pregnant women U07.1 Covid-19 disease Treatment - Drugs Placebo Intervention group: In addition to the standard treatment regimen for covid-19, capsules which have aqueous licorice extract containing 80 mg of the active ingredient glycyrrhizin will be given three times a day for 2 weeks. Licorice capsules are formulated at the Mashhad School of Pharmacy with the ineffective ingredients of Ovisil and Arozil Control group: ]n addition to general drugs for treatment of corona, the patients take placebo capsule 3 times a day for 14 days Time interval until clinical symptoms improve. Timepoint: 3 days, 1 week and 2 weeks after treatment. Method of measurement: Time of recovery. Lymphopenia. Timepoint: 3 days, 1 week and 2 weeks after treatment. Method of measurement: Cell counter device. CRP level. Timepoint: 3 days, 1 week and 2 weeks after treatment. Method of measurement: CRP kit. Mashhad University of Medical Sciences Approved 2020-04-05 Medical Ethics Committee of Mashhad University of Medical Sciences Blv.Vakilabad 2- School of Pharmacy-1365-91775 Mashhad Razavi Khorasan Iran (Islamic Republic of)